MDC1 antisense RNA 1
MDC1-AS primarily exists in the nuclear fraction .
MDC1-AS acts as a tumor suppressor in bladder cancer and exerts positive regulatory effect on its neighboring coding gene MDC1.
MDC1-AS exhibits significant decreases in proliferation,colony formation, migration and invasion.
MDC1-AS may act as a tumor suppressor in bladder cancer .
MDC1-AS levels in cancerous tissues are evidently lower than those in the noncancerous tissues .
MDC1 is down-regulated in bladder cancer tissues, which was concordant with MDC1-AS .
Expression levels of MDC1-AS and MDC1 in tissues are significantly correlated in a positive direction, indicating a potential regulating role of MDC1-AS on the coding gene MDC1 .
The expression levels of MDC1-AS and MDC1 are decreased in bladder cancer cells .
|Experiment||Primer||Forward primer||Reverse primer|
Labs working on this lncRNA
- Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer
Center, Nanjing Medical University, Nanjing, China
- Xue, Y., G. Ma, Z. Zhang, Q. Hua, H. Chu, N. Tong, L. Yuan, C. Qin, C. Yin, and M. Wang. "A Novel Antisense Long Noncoding Rna Regulates the Expression of Mdc1 in Bladder Cancer." Oncotarget 6, no. 1 (2015): 484-93.
>gi|949474747|ref|NR_133647.1| Homo sapiens MDC1 antisense RNA 1 (MDC1-AS1), long non-coding RNA
Predicted Small Protein
|Amino acid sequence||MEAWLFSRGTACGALPSSTSVSLPAWLSCRWARPGAPGPLVPTPWKIFLFFIGMTTGVAG|