- 1 Annotated Information
- 2 Labs working on this lncRNA
- 3 References
MAF transcriptional regulator RNA
linc-MAF-4,a TH1 signature lincRNA, localized 139.5 kb upstream of the MAF gene .
linc-MAF-4, a chromatin associated CD4+ TH1 specific lincRNA .
Linc-MAF-4 plays a key role in T lymphocyte differentiation .
Linc-MAF-4 down-regulation skewed T cell differentiation toward TH2 .
A long-distance interaction between linc-MAF-4 and MAF genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated MAF transcription by recruitment of chromatin modifiers .
Sequencing data showed that high expression of linc-MAF-4 correlated with a low amount of MAF transcript in CD4+ TH1 cells, conversely TH2 cells had low expression of linc-MAF-4 and abundant MAF transcripts .
No correlation was observed between the expression linc-MAF-4 and its proximal upstream protein coding genes: CDYL2 and DYNLRB2 .
>gi|559098521|ref|NR_104663.1| Homo sapiens MAF transcriptional regulator RNA (MAFTRR), long non-coding RNA
Labs working on this lncRNA
- Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, 20122 Milano, Italy .
- Valeria Ranzani, G.R., I.P., A.A., R.JP.B.,S.C., P.G, E.P, E.S, M.M, R.De.F, J.G, B.B, S.A, and Massimiliano Pagani (2015) LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4. Nature Immunology, 16(3):318-25.