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lncARSR, a lncRNA regulator of Akt signaling associated with HCC and RCC

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lncARSR: lncRNA regulator of Akt signaling associated with HCC and RCC


lncARSR (lncRNA Activated in RCC with Sunitinib Resistance) is located on chromosome 9 in humans and composed of four exons with a full length of 591 nt determined by RACE. [1]


lncARSR acts as a ceRNA for miR-34 and miR-449 to promote AXL and c-MET expression [1] . lncARSR promotes the self-renewal capacity, tumorigenicity and metastasis of renal T-ICs [2]. lncARSR plays a critical role in renal T-ICs propagation and may serve as a prognostic biomarker and potential therapeutic target [2]. lncARSR physically associates with PTEN mRNA, promotes PTEN mRNA degradation, decreases PTEN expression, and activates PI3K/Akt pathway [3]. Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis [4]. Upregulated lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathways [5]


Transfection of constitutively active FOXO1 (FOXO1-A3) or FOXO3a (FOXO3a-A3) significantly downregulated lncARSR levels in sunitinib-resistant cells [1]


  • Hepatocellular Carcinoma [3]
  • Renal cancer [1]


lncARSR is preferentially upregulated in renal T-ICs [2] . lncARSR is upregulated in HCC, associated with large tumor size and advanced BCLC stage [3]. Overexpression of lncARSR enhance while knockdown of lncARSR ameliorated hepatic lipid accumulation in vivo and in vitro [4].

Labs working on this lncRNA

  • Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Intensive Care Unit, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, 261031, China
  • Department of Medical Equipment, Weifang People's Hospital, Weifang, Shandong, 261000, China


  1. 1.0 1.1 1.2 1.3 Qu L, Ding J, Chen C, Wu ZJ, Liu B, Gao Y et al. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA[J]. Cancer Cell. 2016, 29(5):653-668.
  2. 2.0 2.1 2.2 Qu L, Wu ZJ, Li YM, Xu ZP, Liu B, Liu F et al. A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells[J]. Nature communications. 2016
  3. 3.0 3.1 3.2 Li YL, Ye Y, Feng BM & Qi Y. Long Noncoding RNA lncARSR Promotes Doxorubicin Resistance in Hepatocellular Carcinoma via Modulating PTEN-PI3K/Akt Pathway[J]. J Cell Biochem. 2017, 118(12):4498-4507.
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