Disease: colorectal cancer (PMID:27077950)
Dysfunction type: NA
Description: Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously. Lnc34a levels affect CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models.
Function Mechanism: transcriptional regulation (PMID:27077950)
Biological Process: pathogenic process