Lnc-FOXC1-1:1

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FOXCUT,a novel long non-coding RNA FOXCUT ( FOXC1 promoter upstream transcript), which co-operated with its neighboring gene FOXC1 as lncRNA-mRNA pair, played a significant role in the oncogenesis and progression of esophageal squamous cell carcinoma (ESCC).

Contents

Annotated Information

Name

FOXCUT,FOXC1 upstream transcript(HGNC nomenclature)

"FOXC1 promoter upstream transcript", TCONS_00011636 [1]

Function

FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.[1]

FOXCUT that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients [1].

Diseases

Esophageal squamous cell carcinoma(ESCC) [1]

Expression

The expression of FOXC1 and FOXCUT.[1]

FOXC1 and FOXCUT were co-overexpressed in ESCC tissue specimens and ESCC cell lines. The expression of FOXCUT and FOXC1 (lncRNA-mRNA gene pair) were both identified to be upregulated in 82 ESCC tissues compared with adjacent noncancerous tissues, and the expression of FOXC1 was also decreased as the FOXCUT expression was downregulated by siRNA.

siRNA primer Forward Reverse
FOXC1 5'- GGCGAGCAGAGCTACTACC -3' 5'- TGCGAGTACACGCTCATGG -3'[1]
FOXCUT 5'- GTCGCACCGATGACTAACG -3' 5'- GCCCTGAAAGCCGAACTG -3'[1]

Labs working on this lncRNA

  • Key Laboratory of Oncology, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing, China [1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Pan F, Yao J, Chen Y, Zhou C, Geng P, Mao H, et al. A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma[J]. International journal of clinical and experimental pathology. 2014,7(6):2838-49.

Basic Information

Transcript ID

lnc-FOXC1-1:1

Source

LNCipedia2.1

Same with

NONHSAT106532,FOXCUT, TCONS_00011636

Classification

intergenic

Length

1366 nt

Genomic location

chr6+:1605724..1607305

Exon number

2

Exons

1605724..1606034,1606251..1607305

Genome context

Sequence
000001 GAGAAACTGG GGCTCGTTCG CGCACACATG CACCATTTGT TCTTTCCGAT CATCTATCCC TTTACGAATT TTATTTTTAT 000080
000081 TCCGGATTGT TAATGCAAGA CGACAGTTTG AATCTCCATT TACCTCTGCC TGAACACAAG AAGCCCTGAG TCTTTTGAAG 000160
000161 CCGGGCACCA AAGTTAAAGA TTCACTTCCC GCATTCCCCA TGGCCCCCTC TTGCAGCTTA GCTCGGCTCT GAGCCCCCGA 000240
000241 AACGCCCTTC GAGGCGGGGG CTTTCCTGCC AAGGGGCGAT AGGTGGGCCA TCCCGAGGCG GGAACGATCA GAAATTTTTC 000320
000321 TACTAAGGAC GGGGCTGAAT TGGAGGGACT GTGCTGACAA ATCCTCTACT TGAAAATCCC CCAGCTAAGG AGTATCTGCC 000400
000401 CAAGGTCGCG GCCACCCAGA TGTTCGGTCC CCACTCCTTC CTCCGCTGAA AAGTCGCACC GATGACTAAC GTTGCCTGCC 000480
000481 GGCCTGGTGG TTTGAAAACG AATGCCGGGC ATTGATGCAA GGATATCCTC CCCTACCCCT GGGATTCTGG TCTAAGCAAA 000560
000561 GGAGGCCGAA TGGAGAACTA AGACAATTAT CTAAGTAATC TAAAAAGCTC AAAGACATCC CCAAGCGGAC CTTGCTCCAG 000640
000641 TGGTCTGTGA TGGCAGCCTA GTGGACAGTT TTCTAGTGGC CCTCTGGGGT TAATTGCCTT AATCTTCCAC TCTGTCTGCC 000720
000721 CCAGCAAAGG GAAAGATGCT AAAGCAGCTG TGGACTTGCA GCCTCCCTCC TGTGTGTGCA GAGCCCCCAG GAATCACTGC 000800
000801 CCCAGTGCAG CAGGAGAAGC GCCTTCCCTC ATGCCCTAAG CCTGCCTTTT CTGTTGTCCC CCAGCTCCTG GGCCAGGTGG 000880
000881 AGCCCCCCCT GAAGCTGGTT TCTACCTGCC CTCGCCTCCC CACTGCAGCC CACAGTTCGG CTTTCAGGGC TGAACCCAGA 000960
000961 GCCCAGAGGA TGGAGAAGCC AGAAAGCGGG GAGGTAAGGG AGAGGGCGTC TAGGCACACC ACAGAGGTGA TTGGGCTGTG 001040
001041 ACGGGGACAA TCCGCACAAC ACGAGCTAAG CTCACACCCC TAGGGAGTGA TTTTTCCGGA CTGCCCCCAT CCCAATCTCC 001120
001121 ACCTCCTCTG CTTTACTTGA AAAAGAAAAA GAAAAAAGAG AGCTCCTTCT GGCTCCTGGT GACCCATATT TAGGACACCA 001200
001201 TCCCATCCCC CAGCACACAC ATTCCTACAG TGTCACCTGG TCCCCAATCC GAGCATTTCC TGGAGTGCTC GCCACATTCC 001280
001281 CCTTCCTGGT GCTTTTCTAT GGTGGGGCCA GGGGAGGCCT TGTTTTGAAC ATCGCTGTGA CGTCACTCCC CCTCCTCCGA 001360
001361 GCTAAG
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