FOXCUT,a novel long non-coding RNA FOXCUT ( FOXC1 promoter upstream transcript), which co-operated with its neighboring gene FOXC1 as lncRNA-mRNA pair, played a significant role in the oncogenesis and progression of esophageal squamous cell carcinoma (ESCC).
FOXCUT,FOXC1 upstream transcript(HGNC nomenclature)
"FOXC1 promoter upstream transcript", TCONS_00011636 
FOXCUT that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients .
Esophageal squamous cell carcinoma(ESCC) 
FOXC1 and FOXCUT were co-overexpressed in ESCC tissue specimens and ESCC cell lines. The expression of FOXCUT and FOXC1 (lncRNA-mRNA gene pair) were both identified to be upregulated in 82 ESCC tissues compared with adjacent noncancerous tissues, and the expression of FOXC1 was also decreased as the FOXCUT expression was downregulated by siRNA.
|FOXC1||5'- GGCGAGCAGAGCTACTACC -3'||5'- TGCGAGTACACGCTCATGG -3'|
|FOXCUT||5'- GTCGCACCGATGACTAACG -3'||5'- GCCCTGAAAGCCGAACTG -3'|
Labs working on this lncRNA
- Key Laboratory of Oncology, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing, China 
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Pan F, Yao J, Chen Y, Zhou C, Geng P, Mao H, et al. A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma[J]. International journal of clinical and experimental pathology. 2014,7(6):2838-49.