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HOTAIRM1: HOX antisense intergenic RNA myeloid 1
Bidirectional transcript with HoxA1. Located between HOXA1 and HOXA2 genes (Sessa (2007), Sasaki (2007), Zhang (2009)). Identified transcript is 483 nt (Zhang (2009)) but other splice isoforms are also likely to be expressed.
HOTAIRM plays a role in the regulation of gene expression during RA-induced myeloid differentiation (Zhang (2009)). Knock-down of HOTAIRM prevented induction of HOXA1 and HOXA4 expression during myeloid differentiation as well as the induction of myeloid differentiation genes CD11b and CD18 (Zhang (2009)). Found to interact with a number of of chromatin binding proteins/complexes in mouse embryonic stem cells including PRC1, PRC2 and CBX1 (Guttman (2011)).
Expressed in the myeloid lineage (Zhang (2009)). Has also been identified as showing a similar expression pattern to HoxA1 and A2 with expression in thymus, muscle, colon, lung, kidney, spleen etc (Sessa (2007), Sasaki (2007)). Induced by retinoic acid (RA) (Sessa (2007), Zhang (2009)). Shows collinear regulation of expression like HOX PTC genes (Sessa (2007)). Expressed in mouse embryonic stem cells (ESCs) (Guttman (2011))
equence quite highly conserved in mammals, with transcripts also detected in mouse and rat (Zhang (2009)).
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Allelic Information and Variation
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Labs working on this lncRNA
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