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~130 nt. 'Alu-like RNA', it has a canonical Alu/7SL-derived sequence structure. Transcribed by RNA Polymerase III from the first intron of the ASCL3 (Achaete Scute-Like homologue 3) gene (Castelnuovo (2010)).
In humans, NDM29 maps in a genomic region whose deletion has been shown to be involved in neuroblastoma development (De Preter (2005)).
In-vitro over-expression of NDM29 promoted differentiation of neuroblastoma (NB) cells into cells with neuron-like features (including marker expression, morphology, anchorage-dependent growth and excitatory properties), and a reduction in the tumor initiating ('stem-like') cell fraction in the NB cell population. In-vitro and in-vivo experiments indicated that increased expression of NDM29 restricts NB development and malignancy. It also lead to reduced expression of multidrug resistance 1 (MDR1) mRNA in malignant NB cells, and so increased their susceptibility to doxorubicin and cis-platinum antiblastic drugs used in NB therapy (Castelnuovo (2010)).
NDM29 expression was analyzed in 6 different cell types and found in abundant levels in neural cells (neuroblastoma cell lines SHSY5Y and SKNBE2, and primary culture of human glioma cells), but at a very low levels in epithelial-derived cells (HeLa, HEK293, and primary cultures of skin fibrobroblast). NDM29 expression was increased in differentiating cells (Castelnuovo (2010)). NDM29 RNA was detected in both the nucleus and cytoplasm of SKNBE2 and HeLa cells, but enriched (~70%) in the latter (Castelnuovo (2010)).
RNA was detected in humans - Alu-derived elements are restricted to primate lineage (Castelnuovo (2010)).
NDM29 transcript comprises Alu sequences and unique sequences and might have been inserted into the genomic locus by retrotransposition (Castelnuovo (2010)). Similar to 21A RNA, it is also a short interspersed nucleotide element, marked as AluJb elements. (Pagano (2007)).
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Allelic Information and Variation
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Labs working on this lncRNA
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