LRP1 antisense RNA 
Lrp1-AS directly binds to High mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1. Short oligonucleotides targeting Lrp1-AS inhibit the interaction of antisense transcript and Hmgb2 protein, and increase Lrp1 expression by enhancing Hmgb2 activity. LRP1-AS negatively regulates LRP1 gene expression through modulating the activity of the non-histone chromatin modifier HMGB2 and LRP1-AS is elevated in the brains of AD patients where it might repress LRP1 expression. 
- Alzheimer’s disease
Depending of the total amount of RNA present in a single cell it has been calculated that one copy of a transcript per cell corresponds to RPKM value between 0.5 and 5. Thus, in the human brain, there is approximately one transcript of LRP1-AS per cell. Decreased expression of LRP1 mRNA levels in AD subjects, while LRP1-AS levels were surprisingly increased.
|Primer||Forward primer||Reverse primer|
- Yamanaka, Y. et al. Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2. Cell reports 11, 967-976, doi:10.1016/j.celrep.2015.04.011 (2015).
>gi|822092842|ref|NR_131939.1| Homo sapiens LRP1 antisense RNA (LRP1-AS), transcript variant 2, long non-coding RNA