LOXL1-AS1

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Annotated Information

Name

Approved Symbol: LOXL1-AS1

Approved Name: LOXL1 antisense RNA 1

Chromosome: 15q24.1

RefSeq ID: NR_040066

OMIM ID: 616800

Ensembl ID: ENSG00000261801

Pubmed IDs: 26307087,30278884,29678575

Characteristics

LOXL1-AS1 expression and prognostic significance in CGGA datasets[1].

Function

  • Silencing LncRNA LOXL1-AS1 was a new regulator of NF-kB signaling pathway through repressing RELB directly, resulting in increased marker genes of PN subtype and decreased those of MES. GBM cell proliferation was functionally suppressed by LOXL1-AS1's knockdown. Furthermore, RELB's rescue could reverse LOXL1-AS1's effects partially in GBM malignant behaviors[1].
  • LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1[2].
  • LOXL1-AS1 plays a functional role in cellular stress response and correlates with the development of the exfoliation syndrome[3].
  • LOXL1-AS1 regulates the proliferation and metastasis of medulloblastoma by activating the PI3K/AKT pathway[4].

Regulation

Diseases

Glioma[1].

Prostate cancer[2].

Exfoliation syndrome[3].

Medulloblastoma[4].

Expression

LOXL1-AS1 is predominantly distributed in the cytoplasm[2]. Compared with proneural, LncRNA LOXL1-AS1 expression is increased in mesenchymal subtype of glioblastoma[1].

Experiment Forward primer Reverse primer
Quantitative real-time PCR 5'-TTCCCATTTACCTGCCCGAAG- 3' 5'-GTCAGCAAACACATGGCAAC- 3'[1]

Evolution

Sequence

>gi|338827654|ref|NR_040066.1| Homo sapiens LOXL1 antisense RNA 1 (LOXL1-AS1), transcript variant 1, long non-coding RNA

000001 GCACCGGCAG GTAGGGCGGC TCCAGCGCGC GCGGCGGCCC GTACGCCTCG GGCGGCGGGT TGGCGTAGGG CGGGTACCAG 000080
000081 CCCAGGCGTG GGTCTCCGCC ATGGGCCTGC GCCGCCTCGG GACCGGGGTC AGGGTGCCAC GGCTTACCAA TGGAAGATTA 000160
000161 GGCCAGATGG CTCCTGAGAG TGCTTTGGGA GATTCTCTGT TCCTTCTGGG AATGGCAGGG ATAGGAGGGG GTCCCAGAAG 000240
000241 TTTGAACGCT TTGGCATCCA AGAAATCACA CTCCAAATAC TGCTCTTCTG GCCTCCCCTG GGCTGCCTTC TCCAACCGTG 000320
000321 TTCCTGGGAA CCGAAGGGCA GAAATTGCCC TCTTGGGCTT ATAAACAAGG AGCTCCTGCC TGCCTGGATG AAGAGGAGGT 000400
000401 CAAGACTTTG TCCCCCACTC CGCAAGATAC CCTCTCTGTT CCGGAGCGGT GGGTCCCTCC CCTGTTAGGA CCTTGTCTCC 000480
000481 CTCAGGACTG GACCTGGATC CTGGGCCTGC AGTCAGATTG CCAGTTTCAC TTAGAGGTGG AAATGTCAAC CCACTGGTTG 000560
000561 GAATGGGAAG GTGAGACAGG ATTTCACCAT GTTAGCCAGG ATGGTCTTGA TCTCCTGACC TCATGATCTG CCCACCTCGG 000640
000641 CCTCCCAAAG TGCTGGGCTT ACAGGCGTGA GCCACCGTGC CCGGCCAAAA ATAACTTTTA AAAACATGAG TATAGCATAC 000720
000721 ACACACACAA AAGTCCACAA ATCCTAGGTG TACCACTTGA TGAATGATCC CAACGTGAGC ACACCTCTGG ATTACCACCT 000800
000801 GGATCAAGAA ATAGGACATC ACAGCAGCTG GCAGCTTCCA AGGAGAAGCT CTGGAAAGTT CTGCCTGTCT CAGCACCTGG 000880
000881 CTGGATCGGA AACGAGTTTT CTTTAACCAG ATTTTTAATG ACTGACTTAT GTGGACAAAT CATAACTGAA TGAATCACCT 000960
000961 CCTTTGTTGA TTTTTTTGGG TACTTTATTT GCTATTATAA ATGATGCTGT AATAAGCACC CTTGAAGAAA TCTTCATATC 001040
001041 TGCCTCTCCT GTGTAGCAGG TCACAGTGCC TGGGTTTGGT TCTAGCCCTC ATTTGTGAAC TGTGTGACTC ACCATGCCTT 001120
001121 TTTTCTTTCT GTAAGACAGG AATAATGGTA AGAATTTAAA TGGGGGTAAT ATGGAGCGCG TTTAGTTCAG AGCCTGGTGC 001200
001201 ATACAAGCAC TCAATAAGTA CTGGCGATTA TTAGACCTTT AGATTAATTT ATTAGAAGTT GGATTTCTGG TGAAAGGGTT 001280
001281 TGAGTGTTTT TGAGGCTTTG GCACAGAATA CCCAGCTGGT CCCAGAAAGG TGGTTCCCAT TTACCTGCCC GAAGGTAATT 001360
001361 CACCCTTACT GATACTGAGT ACTGTTTTCT AAAAGAACAT TAAAAATTGG ATAGGTTAAA AACAGGTGAA TACATTTTTT 001440
001441 TAGTTGCATT TTTTTGGTTA CCCGTGAGAG TGAACATGTT GCCATGTGTT TGCTGACCTC CTAAATGGTC TATTTGCTCC 001520
001521 TACCTTTGTA CCCCAAAAGT CTGCTCTCAA GATGGTAGCC AGAATGATCC TTTTTGAGAC ATAAGTCAAA ATTTCACTCT 001600
001601 TCTCCTTAAA GCTCTGCAAT GGTTCTCAGG TTAAAAGCCA AAGTCCTGTT CAAGGCCTCC AGGGTCCTCA CCACTTGGTC 001680
001681 CCTTGCTCTT TCTGTTCTAG CCAACTTGGC CTTCTCCTGC CCCTCCGCCG CACCATGGCA ATTTCCCCTG CTCTGTGTGG 001760
001761 TCAACTACCT GAATCTGTTC AAAGCTTTGC TCAAATGTCT CCTTCCTGAT GAGACCTCCC CAGCCCCTGA GCTCCCCATG 001840
001841 CCTCACTCCT GATCGCCTTA CTTAACCCTT CTTTTTCTTT TTTGCCAGTA GTACTTATCA CCGTCTAAAA TACTTCATAA 001920
001921 TTTACTTGTT TATTGTTTGC CCCTCTCCAA TAGAATGTAA GCTCCTTGGG GCAGGGACCT TTGTCCTTTG TCTTGTTCAC 002000
002001 TGCTGTGTCC CATGTGTAAA CTTGTCTGGC ACAGAAGAGG TGCTCGATAA ATATTTGTTG AGTGAATGAA TGGTAAATTT 002080
002081 TCTGTTCATA TTCTTTGACT ATTTTCTATT GTAATGTTCA TCTTTTTAGT ATTGGTTTAT AAGATGTATA TTTAGCACCT 002160
002161 TTTCATATAT CACTCTTTGT CACATATTAT GCAACTAATT TGTCATTTCC ATCAATTTTT AAAATACTTT CTTGATGCTT 002240
002241 CATTTTTAAG CTGTCAGATT ATTAATCTTT TCTTTATGGT CTTGGACTTT ATTGTTGCAT AACCGCTGCC TTCACCAGGA 002320
002321 ACATATAAAT TTTCAATTAA ATGTTCTTCT GAGATTTTAT GATTTCACTT TTTATATTAA ACTCTTCATT TTGTCTTCAT 002400
002401 GTGTGGTGAG AGGTAAGAAC ATAACTTTAA AGCAAATTAA CCAACTATCC CCAAATGAAT TATAAATAAA TTAATCATTT 002480
002481 TCCAATAAAA AAAAAAAAAA A

Labs working on this lncRNA

  • Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian City, 116023, PR China

References

  1. 1.0 1.1 1.2 1.3 1.4 Wang H , Li L , Yin L . Silencing LncRNA, LOXL1-AS1, attenuates mesenchymal characteristics of glioblastoma via NF-κB pathway[J]. Biochemical and Biophysical Research Communications, 2018:S0006291X18309148.
  2. 2.0 2.1 2.2 Long B, Li N, Xu X X, et al. Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1[J]. Biochemical and Biophysical Research Communications, 2018.
  3. 3.0 3.1 Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the\r, LOXL1\r, locus[J]. Human Molecular Genetics, 2015, 24(22):6552-6563.
  4. 4.0 4.1 Ran G , Rui Z , Cuicui Z , et al. LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activating the PI3K/AKT Pathway[J]. Analytical Cellular Pathology, 2018, 2018:1-11.