Disease: psychiatric disease (PMID:23831425)
Dysfunction type: regulation
Description: Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels.
Function Mechanism: transcriptional regulation (PMID:23831425)
Biological Process: pathogenic process