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Annotated Information


LIVAR:liver cell viability associated lncRNA.

RP11-484N16.1 [1]

lnc18q22.2 [1]


The length of lnc18q22.2 transcript is estimated to be 633 bp [1].

Cellular Localization

Lnc18q22.2 is mainly present in cytoplasm [1].


Association of lnc18q22.2 expression with different degrees of NASH[1].

Lnc18q22.2 is significantly associated with NASH (Nonalcoholic steatohepatiti) grade, lobular inflammation, and NAS (AFLD activity score) [1]. In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis (including ASH (alcoholic steatohepatit) and NASH) [1]. Knockdown of lnc18q22.2 results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells [1].


Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino) cell line HepG2 [1].


Nonalcoholic steatohepatiti [1]

Labs working on this lncRNA

  • Department of Pediatrics, Molecular Genetics, University Medical Center Groningen, Groningen, The Netherlands.


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 Sep;66(3):794-808.