LIVAR:liver cell viability associated lncRNA.
The length of lnc18q22.2 transcript is estimated to be 633 bp .
Lnc18q22.2 is mainly present in cytoplasm .
Lnc18q22.2 is significantly associated with NASH (Nonalcoholic steatohepatiti) grade, lobular inflammation, and NAS (AFLD activity score) . In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis (including ASH (alcoholic steatohepatit) and NASH) . Knockdown of lnc18q22.2 results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells .
Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino) cell line HepG2 .
Nonalcoholic steatohepatiti 
Labs working on this lncRNA
- Department of Pediatrics, Molecular Genetics, University Medical Center Groningen, Groningen, The Netherlands.
- Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 Sep;66(3):794-808.