LINP1

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Annotated Information

Expression and genomic alteration of LINP1 in breast cancer[1]
LINP1 RNA associates with Ku80 and DNA-PKcs[1]
LINP1 serves as a modular scaffold in the NHEJ pathway[1]

Approved Symbol

LINP1 (lncRNA in non-homologous end joining pathway 10

Chromosome

10p14

RefSeq ID

NR_138480

Expression

Compared with the non-basal lines, LINP1 has significantly higher expression level. [1]

Function

LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. [1] Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.[1]

Regulation

LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. [1]

Labs working on this lncRNA

  • Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Zhang, Y., et al., Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol, 2016. 23(6): p. 522-30.