LINCADAL
LINCADL, human subcutaneous adipose lincRNA associated with obesity
Contents
Annotated Information
Approved Name
Approved symbol:LINCADL
Approved name:lincRNA adipogenesis and lipogenesis associated
HGNC ID:HGNC:53956
Alias symbol:linc-ADAL
RefSeq ID:NR_157226
Characteristics
LINCADL is located between protein-coding genes AQPEP and AP3S1 on chromosome 5 [1]. RNAseq, 3′ RACE (rapid amplification of cDNA ends), and the 5′ TSS identified by CAGE (35) in human adipocytes suggest that LINCADL has two alternatively spliced isoforms sharing the same promoter and isoform 2 is the main adipose transcript [1]. Phylogenetic information–based codon substitution frequency (PhyloCSF) analyses suggested that the two LINCADL transcripts had low probabilities of containing open reading frames for coding sequences [1].
Function
LINCADL regulates adipocyte differentiation and modulates de novo lipogenesis in mature adipocytes [1]. LINCADL modulates IGF2BP2 posttranscriptional regulation of distinct metabolic genes in adipocytes [1]. LINCADL interacts with hnRNPU in the nucleus and insulin-like growth factor 2 mRNA binding protein 2 in the cytoplasm [1].
Regulation
LINCADL expression was reduced in mature adipocytes treated with GW9662, a PPAR antagonist [1].
Diseases
- Obesity [1].
Expression
LINCADL is highly expressed in adipose tissues [1]
Labs working on this lncRNA
- Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
- Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
- Division of Cardiovascular Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
- Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
References
Sequence
>gi|107986443|ref|NR_157226.1|Homo sapiens lincRNA adipogenesis and lipogenesis associated (LINCADL), long non-coding RNA
000081 AAACACAGGA TTCATCAGCA TATGTGTGGT TTCTGAACCT ATGGGACAGG ATGGCATCAC TCAGGGAAAG AGCACAGAGT 000160
000161 CAGAAGAAAA TATGACCCAA GACCAGGCCT TGAAGAACTC CGATATTTAA TGTTTGGGTA GAAGAAAAGG CAAACGAAAG 000240
000241 TATCTGAAAA GATGGGCCAG AGAAGAGAGA ATCAACCAAG GGGAGATGGT CCCAGAAGTC AAACAGAAGG GAGTGATTCG 000320
000321 CTGTGATGAA TGCTGCAGAG GCCAAATAAG GAAAAGAAGA CAGCAAGAAG AAGCCACTTT GAGCCCCTAT GATTTCATCT 000400
000401 TTGATCCACT CATCCAGCAC TCCATACTCC TTGATCCCTA CCCACCAAAT TCTCCTTAAA AGCCCTGGTC TCCAAATGTT 000480
000481 CAAGGCGACC GATTTGAGTA ATAAAACTCT AGTCTCCCAT TTA
