LINC01844 （long intergenic non-protein coding RNA 1844）
LINC01844 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.
Compared with the control tissues, the expression of LINC01844 is down-regulated in hirschsprung disease (HSCR) tissues.
|Experiment||Forward primer||Reverse primer|
|qRT-PCR||5'-AACCCAGTGTTCAAAACCCCA- 3'||5'-GCAGGGGAAAATACCAGGGAA- 3'|
SiRNA experiment shows that LINC01844 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition. The expression correlation analysis shows LINC01844 regulate the expression of FGF1.
Labs working on this lncRNA
- Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
- State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China.
- Shen, Z., et al., Downregulated Expression of Long Non-Coding RNA LOC101926975 Impairs both Cell Proliferation and Cell Cycle and Its Clinical Implication in Hirschsprung Disease Patients. Int J Med Sci, 2016. 13(4): p. 292-7.