LINC00941
Contents
Annotated Information
Name
Approved symbol: LINC00941
Approved name: LINC00941: long intergenic non-protein coding RNA 941
HGNC ID: HGNC: 48635
Ensembl ID: ENSG00000235884
LncBook transcript ID: HSALNT0289072
Characteristics
Function
- Depletion of lncRNA-MUFs in HCC cells repressed EMT and inhibited their tumorigenic potential. Conversely, lncRNA-MUF overexpression accelerated EMT and malignant capacity. Mechanistic investigations showed that lncRNA-MUFs bound Annexin A2 (ANXA2) and activated Wnt/β-catenin signaling and EMT. Furthermore, lncRNA-MUF acted as a competing endogenous RNA for miR-34a, leading to Snail1 upregulation and EMT activation[1].
- lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation[2].
Regulation
Diseases
Hepatocellular cancer[1].
Expression
LINC00941 is enriched in human progenitor keratinocytes[2].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Quantitative real-time PCR | 5'-GACCTTTTCAGGCCAGCATT- 3' | 5'-ACAATCTGGATAGAGGGCTCA- 3'[2] |
Evolution
Sequence
>NR_040245.1 Homo sapiens long intergenic non-protein coding RNA 941 (LINC00941), long non-coding RNA
000001 GGGGACGTGG CTGAAGTCAG TCGGGCCGCC CGCTTGCTGC ACGGCAGCCG TGGGACTGGC ACAGGCTCCT CGGCAGCATT 000080
000081 ATGGGCAGCT GGTAGAGCGG CCACTTCTGA GAGCCGGATG GGCCTTCCGA GGTCGGGCCG TGCCCCGCTG GGCAGCGCAG 000160
000161 AGGGGGTGTG TAGGGCACGC GACTTGGAGC CAGGTCCAGA CCCATCCTGG CTCCTCTCAG GGCTCCTTCC CCTGCCCCCA 000240
000241 TTCCACCCCA GCCCTGCTGG CTGTCCCGCA GGACCCAGCG CCGCGGTAGC CTTCTCTGAA CTGCGGCTCA GGCGGAGGTG 000320
000321 TCACTCCTGC CTCCAGCCCA GGAGGGCAGG TCAGGTTATG CAACGCGTGC CGCGCGATCT CCCCCCACCT CCAACCCCCT 000400
000401 TTTCTCCCGG GTCCACACCG CAGTTCCCAC CGCTCCGGGT GTCCTCCCCA GTGCGCCGCG ATTTTTGTGT CCAAGCCCCA 000480
000481 GAGTCCCTCT GAGACCAACC CCCAGCCAGC ACAGACTTCC TGCCTTCCCA GCTCGGGGAT GTGGTCTCAT TAGGTTGCCC 000560
000561 AAGCTGGACT TGTACTCTTG GCCTCAAGAG GTCCTTCCAT CTCAGTCTCC CAAGTAGCTG GGACTACAAG CATGCACCAC 000640
000641 TACACTCAGC CAAATACTTT CAATAATTTG CCAGCTGACA ACTTGATTGG GTTCTCCTTC AGGTTTGAAG CGCCCTCGAG 000720
000721 AAGTGTCTAA AGGAGACAGT TGATAGCCAA ACAACAGTTT TGGATTCACT GACTGATTAT GAAAGAAGCA GTAGACTGGT 000800
000801 ATCAAGAATC AGTCAGCAAG GAGGCCCTCA CCAGACGCCA GTGCCATGTT CTTGGACTTC TCAGCCTCCA TATTCATGAA 000880
000881 CTAAGTTTTT GGAATCCTTA GGCTTCCACG TGTGGAAAGC CTGAGCTAAC CTACTGGAGG ATGAGCCATC ACCTGGAGCA 000960
000961 GATTCAGGCC ATCCTAGTTG AAGCCTCCCT AGGCCAAGCA ACCGTCCAAC TACCAGACAT TGACCATTCA GCCTTGAACA 001040
001041 TTCAGCACAA AGACAAAACA GACCAGACCA GAAGAGTCCC ACAGAATAGG GGAAACTATT CAGAGAAAAC TTAAGCCACT 001120
001121 AAGTTTTATG GTGTTTTGTT CTGTAGCAGA AGCATAGGCA TACTGACAAT ACAAACCGAA ATCCTTCTAA CGTAGTGGAC 001200
001201 CTTTTCAGGC CAGCATTTTT TCCTTGAAAA CCTGGAGCAT GTATCCATCT TATAGCAGAG ATCACTTTCA CAATGTTTGG 001280
001281 GCTCTTGATT TGAATTGATG ATGTAATGAG CCCTCTATCC AGATTGTAAC TAATTACTCT GCGAATTGAC TGGATTCCAC 001360
001361 ACCCTTCTAA TATTTTACTT TTCCTCTTTT ATCAACTCTC ATTCTTGCTG CCATGATCAA TGGACCAACT ATGCTTATAA 001440
001441 CCACAAATTT TGATATGCTT AAACAAATGA ACAAATATAT TTAATAATTT CTTTTTTTTT TTTGAAATAG TATCTTGCTC 001520
001521 TGTCACCCAG GCTGCAGTGC AGCAGCGTGA TCTCAGCTCA CTATAACCTC CACCTCCCGG GTTCAAGTGA TTCTCCTGCC 001600
001601 TCAGCCTCCC AAGTAGCTGG GACTACAGGC GCCCACCACC ATACCTGGCT AATTTTTTGT ATTTTTAGTA GAGACAGGGT 001680
001681 TTATCCATGT TGGCCAGGCT GGTCTCAAAC TCCTGACCTC AAGTGATCCT CCTGCCTCGG CCTCCCAAAG TGCTGGGATT 001760
001761 ACAGGTGTGA GCCACCATGC CCAGCCAATA ATTTCCTGAT ATAATAAAAA TGCCAATACT ATACAATTAA ATAGTAAAGT 001840
001841 GATAAAAAAT AGGATAACAT GATAACCACT AATTAATATA TACTACATAA TCATC
000081 ATGGGCAGCT GGTAGAGCGG CCACTTCTGA GAGCCGGATG GGCCTTCCGA GGTCGGGCCG TGCCCCGCTG GGCAGCGCAG 000160
000161 AGGGGGTGTG TAGGGCACGC GACTTGGAGC CAGGTCCAGA CCCATCCTGG CTCCTCTCAG GGCTCCTTCC CCTGCCCCCA 000240
000241 TTCCACCCCA GCCCTGCTGG CTGTCCCGCA GGACCCAGCG CCGCGGTAGC CTTCTCTGAA CTGCGGCTCA GGCGGAGGTG 000320
000321 TCACTCCTGC CTCCAGCCCA GGAGGGCAGG TCAGGTTATG CAACGCGTGC CGCGCGATCT CCCCCCACCT CCAACCCCCT 000400
000401 TTTCTCCCGG GTCCACACCG CAGTTCCCAC CGCTCCGGGT GTCCTCCCCA GTGCGCCGCG ATTTTTGTGT CCAAGCCCCA 000480
000481 GAGTCCCTCT GAGACCAACC CCCAGCCAGC ACAGACTTCC TGCCTTCCCA GCTCGGGGAT GTGGTCTCAT TAGGTTGCCC 000560
000561 AAGCTGGACT TGTACTCTTG GCCTCAAGAG GTCCTTCCAT CTCAGTCTCC CAAGTAGCTG GGACTACAAG CATGCACCAC 000640
000641 TACACTCAGC CAAATACTTT CAATAATTTG CCAGCTGACA ACTTGATTGG GTTCTCCTTC AGGTTTGAAG CGCCCTCGAG 000720
000721 AAGTGTCTAA AGGAGACAGT TGATAGCCAA ACAACAGTTT TGGATTCACT GACTGATTAT GAAAGAAGCA GTAGACTGGT 000800
000801 ATCAAGAATC AGTCAGCAAG GAGGCCCTCA CCAGACGCCA GTGCCATGTT CTTGGACTTC TCAGCCTCCA TATTCATGAA 000880
000881 CTAAGTTTTT GGAATCCTTA GGCTTCCACG TGTGGAAAGC CTGAGCTAAC CTACTGGAGG ATGAGCCATC ACCTGGAGCA 000960
000961 GATTCAGGCC ATCCTAGTTG AAGCCTCCCT AGGCCAAGCA ACCGTCCAAC TACCAGACAT TGACCATTCA GCCTTGAACA 001040
001041 TTCAGCACAA AGACAAAACA GACCAGACCA GAAGAGTCCC ACAGAATAGG GGAAACTATT CAGAGAAAAC TTAAGCCACT 001120
001121 AAGTTTTATG GTGTTTTGTT CTGTAGCAGA AGCATAGGCA TACTGACAAT ACAAACCGAA ATCCTTCTAA CGTAGTGGAC 001200
001201 CTTTTCAGGC CAGCATTTTT TCCTTGAAAA CCTGGAGCAT GTATCCATCT TATAGCAGAG ATCACTTTCA CAATGTTTGG 001280
001281 GCTCTTGATT TGAATTGATG ATGTAATGAG CCCTCTATCC AGATTGTAAC TAATTACTCT GCGAATTGAC TGGATTCCAC 001360
001361 ACCCTTCTAA TATTTTACTT TTCCTCTTTT ATCAACTCTC ATTCTTGCTG CCATGATCAA TGGACCAACT ATGCTTATAA 001440
001441 CCACAAATTT TGATATGCTT AAACAAATGA ACAAATATAT TTAATAATTT CTTTTTTTTT TTTGAAATAG TATCTTGCTC 001520
001521 TGTCACCCAG GCTGCAGTGC AGCAGCGTGA TCTCAGCTCA CTATAACCTC CACCTCCCGG GTTCAAGTGA TTCTCCTGCC 001600
001601 TCAGCCTCCC AAGTAGCTGG GACTACAGGC GCCCACCACC ATACCTGGCT AATTTTTTGT ATTTTTAGTA GAGACAGGGT 001680
001681 TTATCCATGT TGGCCAGGCT GGTCTCAAAC TCCTGACCTC AAGTGATCCT CCTGCCTCGG CCTCCCAAAG TGCTGGGATT 001760
001761 ACAGGTGTGA GCCACCATGC CCAGCCAATA ATTTCCTGAT ATAATAAAAA TGCCAATACT ATACAATTAA ATAGTAAAGT 001840
001841 GATAAAAAAT AGGATAACAT GATAACCACT AATTAATATA TACTACATAA TCATC
Labs working on this lncRNA
- Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany.
References
- ↑ 1.0 1.1 Yan X , Zhang D , Wu W , et al. Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a[J]. Cancer Research, 2017, 77(23):canres.1915.2017.
- ↑ 2.0 2.1 2.2 Ziegler C, Graf J, Faderl S, et al. The long non‐coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis[J]. EMBO reports, 2019, 20(2).
