LINC00850 spanning nearly 50kb on Xq28 specially expressed in brain, which indicated a potential role in mental retardation.
LINC00850:long intergenic non-protein coding RNA 850(HGNC nomenclature)
LINC00850(alse named KUCG1) spans nearly 50kb onXq28 and is located 9.0kb downstream of MAGEA1 and 4.4kb upstream of MAGEA8. It has three exons separated by two introns(32kb and 20kb long, respectively). Its intron 1 encompassed the site of recombination of the intrachromosomal inversion inv(X)(p21.2; q28), which cause a a head-to-tail fusion of KUCG1 and dystrophin at the recombination sites. Exon 3 of KUCG1 overlaps with antisense transcript RP5-869M20.2, an lncRNA of unknown function.
It belongs to the category of "Intergenic" in lncRNA classification.
KUCG1 disruption may responsible for the moderate mental retardation in the index case as it was expressed in the brain..
- Duchenne muscular dystrophy
KUCG1 was specially expressed in brain.
Primer used as follows
>gi|565324244|ref|NR_109813.1| Homo sapiens long intergenic non-protein coding RNA 850 (LINC00850), long non-coding RNA
Labs working on this lncRNA
- Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan..
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Tran TH, Zhang Z, Yagi M, Lee T, Awano H, Nishida A, et al. Molecular characterization of an X(p21.2;q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28[J]. Journal of human genetics. 2013,58(1):33-9.