LINC00574

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LINC00574 is a lincRNA that is associated with chemoresistance in primary breast cancer.

Annotated Information

Name

Approved symbol: LINC00574

Approved name: long intergenic non-protein coding RNA 574.

Previous symbols: C6orf208.

Alias symbols: FLJ13162, dJ182D15.1, CRALA.

HGNC ID: HGNC: HGNC:21598

RefSeq ID: NR_026780

Characteristics

Function

LINC00574 silencing in chemoresistant breast cancer cells resensitizes cells to chemotherapy[1].
  • LINC00574 might be a target to reverse chemoresistance in breast cancer patients.[1].

Regulation

Diseases

Primary breast cancer[1].

Expression

Non-responding tumors (poor response to chemotherapy, 32 samples) had fourfold higher LINC00574 expression than responding tumors (good response to chemotherapy, 47 samples). LINC00574 is upregulated in chemoresistant breast cancer cell lines compared to their parental lines[1].

Experiment Forward primer Reverse primer
Quantitative PCR 5'-CTCACTCCTCTGCCGATGCT- 3' 5'-CCACACCAGGACCATTCTCTTG 3'[1]

Evolution

Sequence

>NR_026780.1 Homo sapiens long intergenic non-protein coding RNA 574 (LINC00574), long non-coding RNA
000001 GTGCTTGACT GGAGGAGGGC TGGCAGCAGA AGTGCAGCTG ACCGGGTTGC GTTTTCGTAC GGCTGACTAA AGCGGATACC 000080
000081 GGTGGCGACT CATTTCTCGT TTTATTTTTC AACGATTTGG CGGAGAAGCT CCTCTTGTGA ATGGACTTTG GATTTCTTGG 000160
000161 AGCTGCGCTG CGGGTCCCAC AGTGTGGCTT TCGGCCCGTG CTGTGCTGGC GCCTGCACTT CCTCTGGCGG GGCACGGGGT 000240
000241 GGCGCTCCCT GGTAAAGCAG CGGCCAGGGG GAGCCGTGAG TGAGGCGCTG CCTCTCCCGC TGAAGCGGGT TCCAAGGCCA 000320
000321 CCGTGAGGGG GACCATCCAT CCAGGAGAGT ACTGGGCAGG CTGCAAATGT CTGTGTTAAA ACAGCTCTGC TGGGCTAAGA 000400
000401 CAGGACAGAA GCAGACAGCA GGTGGATGAG ACACAATTTC CTATCCAGCA GAACCTGCAG CAAGCTCCAC AGCACCCTCC 000480
000481 ATGGGCTCAG TCTTGCTCCC GGGAAGATGG TTAATTCCAT CAGCTCCTTC TGGCCGGCAG CAGGAAGAGT GGCCCTGTGT 000560
000561 GTGCCAGGCC CTGCAGTCTC TCCTCTCAGC TGGTGTCTCC AGTGAGGGAC CTGAGTCATC GCACACATGA GCCTGTGCTC 000640
000641 AGCCTGCACA TCTCCCGCCT CCCACCAGCT GCTCCTCAAC TGCCAGGGCC AGACTGTGGC AAAATCTCAC TCCTCTGCCG 000720
000721 ATGCTGGGGT TTCCCTCGTG TCTGGGAGGT GGTGTGCTTG GTGGCCTGAG CACTGCAGTG AATCCATGTT TCCCTCCCAG 000800
000801 CACCCTGTTC TGTCCTCCAA CTTGGCCGAC AGCTCTGGCC AGGGACGCAG CCCAGCTGGT GCCCACCCCG CACTCTGTCC 000880
000881 ATTTCATAAG AGCCCTTGGT TTCCTCACTT CCCTCAGATT TTGCCAAGAG AATGGTCCTG GTGTGGCCCA GAAAGGCCAG 000960
000961 CGGGGTGCAG CCTGGGACTG AAAGCAGAGG CGGCTCTGGT GGGGAAAAAG TAGCTCTCCC AGCCTAGCCC TACTGGTGGG 001040
001041 CGGCACCTCC TGGCTCCAGG CCATCTTTTG TCCCAGTCCT AGGTAAGAAA AACACAAACA AAAGCCAGTC CCATGGCACT 001120
001121 CGAGAAGCAG GAGGCCGTTC CCTGACAGCA ACATGCTGTG TGCACAGACA CACGGGTGGA CAGGAGGCAG AGCTCGGGGT 001200
001201 TGCTGCGGAG CGGGCAGGAC ACTGGAGCGG CAGGCAGTGC GGACCCGCCG GGCAGCCGTG CACGGTTGTC GTCCTCAGCG 001280
001281 GCAGGAGCCA GTTTGTTGCT CAGGGCCTTG TCTTTTTACA AAGAGCCCCA GGCCCCGGGG GCTTCTCTGG GTGCCTCTTT 001360
001361 GCTGCCATGT CTGCACGCGG GCGGAGAGCA GACCAGGCTA CCGACCCTCT CGCTTTGCTG TCTTCACGTG GAAAAGCCAG 001440
001441 TGTCGTAGCC CCAAAGGAGG GGAAACTGTA TTGATTTGGG GAGCCTCTAT GTTGATTTCA AAACAGATTG TCTCCTGTGT 001520
001521 TCTCAAAGAC TGGAAGCGAA CCCCACAACC GCCTTAGGCC ACAAAAGCTT TATCCTTTCT AATTAGCATC CCTGTGACCT 001600
001601 GCTCTGCGCC CTGCAGATAT TTTGCTCAGC CAGCCAGAAG GAGGGAGGCC AGACACCAGC CCCCACAGAC CTGCGGCTGC 001680
001681 GACCCCCTGC CTGGGGACGA TGGGGTCGGG GTCCAGTAGC TGCCCCAGAA ACAAGTGGGG CTGCAGGAGG CTGATGGTGA 001760
001761 GCTTGGAGGT TGGCAGAATT CTAAATCTGG GCACTGCAGG GTCCCCACAG GTCACGACCC TACTCTGCTC CACCCAGGCT 001840
001841 CCGGAGGACC TGAGCAGGAA CCTCTGCAGG GGGGGCCCGG GGCTCCCTGT CCTCTCAGCA GCCGGCAGTG CTCCCTGACA 001920
001921 GCCCGGGCCT CTCCCTCCAG TAGTTCGGTA GTTTGCTGTC ACCAACATGG CTGGGCCTGG GACAGGCTCC TCCTCTCCCT 002000
002001 CCAGAAGCCA GGCAGTCCCT CCTGCCTCAG TTTCTCAGAC TAGGCCGCCT CTCCCATCGC GAGACACTGA AGACCCTCAG 002080
002081 CTGTTTCCAT CTGCCCAGTC TGACTGCTGG ATCGCCCTCT GTGTGCGTTG GTTTGCTGTG TTCTTGCTAC TCGCCCTTGG 002160
002161 ATAAGATTTC TTCTCTACTC ATGAAGCTGC GTGTCCTGGA GGGCAGGGCC GCACCTCACA TGCATGTTGC CCACATAGCT 002240
002241 CAGCAACAGA TGCTCTCACG CTTGTTAAAA GTAAAACCGG GCCAGGCGCA GTGGCTCACG CCTGTAATCC CAGCACTTTG 002320
002321 GGAGGCCGAG GTGGGTGGAT CACCTGAAGT CAGGAGTTTG AGACTAGCCT GACCAACATG GAGAAATCCC GTCTCTACTA 002400
002401 AAAATACAAA AAATTAGCTG GGCGTGGTGG CACATGCCTG TAATCCCAGC TACTCGGAGG CAGGAGAATT GCTTGAACCC 002480
002481 AGGAGGCGGA GGTTGCGGTG AGCCAAGATC ACGCCATAGC AATTGCACTC CGGCCTGGGC AACAAGAGCA AAACTCTGTC 002560
002561 AAAAAG

Labs working on this lncRNA

  • Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 Li Y , Wang B , Lai H , et al. Long non-coding RNA CRALA is associated with poor response to chemotherapy in primary breast cancer[J]. Thoracic Cancer, 2017.