LINC00163 encoded on the reverse strand of NLC1 on chromosome 21q22.3 play a role in human narcolepsy.
LINC00165: long intergenic non-protein coding RNA 165 (HGNC nomenclature)
"narcolepsy candidate-region 1 gene B", NLC1-B
NLC1-B, encoded in NLC1 (a candidate region for susceptibility/resistance to human narcolepsy ), is on the reverse strand on chromsome 21q22.3 with positions 45238709-45239923.
It belongs to the category of "Intergenic" in lncRNA classification.
SNP rs13048981 is located 2,602 bp upstream of NLC1-B, which was not expressed in human brain, and its position, 4,164 bp upstream of NLC1-A, suggests that its association with narcolepsy resulted merely from the LD with rs13046884 and D21S0012m. Thus, it is unlikely that NLC1-B is a susceptibility/resistance gene for human narcolepsy.
- human narcolepsy
|RT-PCR||Forward primer||Reverse primer|
>gi|22800663|gb|BC009635.1| Homo sapiens chromosome 21 open reading frame 135, mRNA (cDNA clone IMAGE:3891427), with apparent retained intron
Labs working on this lncRNA
- From the Departments of Sleep Disorder Research (Alfresa) (M.K.; T.E.) and Human Genetics (M.K.; H.H.; K.T.), Graduate School of Medicine, University of Tokyo, the Japanese Red Cross Central Blood Center (T.J.), and the Neuropsychiatric Research Institute (Y.H.), Tokyo; and the Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan (G.T.; A.O.; H.I.) .
- Kawashima M, Tamiya G, Oka A, Hohjoh H, Juji T, Ebisawa T, et al. Genomewide association analysis of human narcolepsy and a new resistance gene[J]. American journal of human genetics. 2006,79(2):252-63.