LIF-AS1:LIF antisense RNA 1
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA .
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs .
The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability .
ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs .
Cervical squamous cancers 
Labs working on this lncRNA
- Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
- Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.