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Annotated Information

Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.[1]
Regulatory function of KRT7-AS overexpression to KRT7.[1]
Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.[1]

Approved Symbol

KRT7-AS (KRT7 antisense RNA 1)






KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.[1]


KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7-AS is 61 and 41 fold lower than KRT7 mRNA (P<0.01).


KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA stability and protect KRT7 mRNA from degradation.[1] The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.[1]


gastric cancer [1]

Labs working on this lncRNA

  • Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  • Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Huang, B., et al., Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene, 2016. 35(37): p. 4927-36.