HOXA13, the most distal member of the HOXA gene with a prognosis role of in human solid tumors
HOXA13: homeobox A13
HOXA13 is the most distal member of the HOXA genes, is located on chromosome7.  HOXA13 belongs to The homeobox (HOX) genes which are an evolutionarily highly conserved gene family of homeodomain-containing transcription factors, which play critical roles in regulating embryonic development.  HOXA13 is a marker of gut primordia posteriorization during development, plays a crucial role in extra-embryonic vascularization and is involved in leukemogenesis. 
In the developing limb, HOXA13 localizes to discrete domains within the interdigital and interarticular regions, where its function is required for interdigital programmed cell death (IPCD), digit outgrowth and chondrogenesis  HOXA13 plays major role in development of HCC.  A plenty of studies showed that elevated HOXA13 expression in tumor tissue was correlated with poor survival of patients with various solid tumors 
Primary human fibroblast manipulation via siRNAs directed against HOTTIP RNA resulted in a concomitant reduction of HOXA13 levels 
- Hand-foot-genital syndrome 
- Hepatocellular carcinoma 
- Preaxial deficiency, postaxial polydactyly, and hypospadias 
HOXA13 overexpression is found in poor OS in human cancer, Histological grade and TNM stage.HOXA13 shows significant overexpression in lymph node metastasis.  HOXA13 might be a valuable biomarker of poor prognosis. 
Labs working on this lncRNA
- Institute of Pathology, Molecular Pathology Division, University Hospital of Basel, Basel, Switzerland
- Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA
- Research Group Human Genetics, Department of Biomedicine, University of Basel and Division of Medical Genetics, University *Children's Hospital, Basel, Switzerland
- Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy
- Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
- Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
- Wen YA, Shu FP, Chen YD, Chen YW, Lan Y, Duan XL et al. The prognostic value of HOXA13 in solid tumors: A meta-analysis[J]. Clin Chim Acta. 2018, 483(64-68
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- Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A et al. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients[J]. Hepatology. 2014, 59(3):911-923.
- Stadler, H. S., Higgins, K. M. and Capecchi, M. R. (2001). Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development 128,4177 -4188
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- Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression[J]. Nature. 2011, 472(7341):120-U158.
- Verp MS. Urinary-Tract Abnormalities in Hand-Foot-Genital Syndrome[J]. Am J Med Genet. 1989, 32(4):555-555.
>gi|3209|ref|NM_000522.4| Homo sapiens homeobox A13 (HOXA13), mRNA