HIF1A antisense RNA 1
Previous Symbols & Names
HIF1A antisense RNA 1 (non-protein coding)
There are two antisense lncRNAs at the 5'(5'aHIF-1A or HIF1A-AS1) and 3'(3'aHIF-1A) ends of the human HIF-1A gene, and they are recovered mainly in the nuclear fractions. 
HIF1A-AS1 is activated in response to partially different kinds of stress, such as low oxygen tension and Top1-mediated transcriptional stress and DNA damage. Suppression of the lncRNA HIF1A-AS1 by siRNA in VSMCs will reduce cell apoptosis and promote cell proliferation.
HIF1A-AS1 expression is up-regulated by 3.26-fold compared with control by BRG1 overexpression, and down-regulated to 0.37-fold by BRG1 silencing.
>gi|537361086|ref|NR_047116.1| Homo sapiens HIF1A antisense RNA 1 (HIF1A-AS1), long non-coding RNA
Labs working on this lncRNA
- Department of Biochemistry “G. Moruzzi”; University of Bologna; Bologna, Italy .
- Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China .
- Shuwei Wang, Xiwu Zhang,Yang Yuan, Mengwei Tan, Le Zhang, Xiang Xue, Yan Yan,Lin Han and Zhiyun Xu."BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro." European Journal of Cardio-Thoracic Surgery 47 (2015) 439–446.
- Bertozzi, D., R. Iurlaro, O. Sordet, J. Marinello, N. Zaffaroni, and G. Capranico. "Characterization of Novel Antisense Hif-1alpha Transcripts in Human Cancers." Cell Cycle 10, no. 18 (2011): 3189-97.