HELLP associated long non-coding RNA
LINC-HELLP, "long intergenic non-protein coding RNA associated with HELLP syndrome"
- HELLP syndrome
HELLPAR is a transcript of 205,012 bases and is localized in early placenta extravillous trophoblasts.
HELLPAR is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.
HELLPAR has been found to be expressed in nucleus, perinuclear region, and cytoplasm, both in vitro — in the extravillous trophoblast cell line (SGHPL-5)and in vivo .
Labs working on this lncRNA
- Department of Clinical Chemistry and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands..
- van Dijk, M., H. K. Thulluru, J. Mulders, O. J. Michel, A. Poutsma, S. Windhorst, G. Kleiverda, D. Sie, A. M. Lachmeijer, and C. B. Oudejans. "Hellp Babies Link a Novel Lincrna to the Trophoblast Cell Cycle." J Clin Invest 122, no. 11 (2012): 4003-11.