GDNF-AS1

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Annotated Information

Approved Symbol

GDNF-AS1:GDNF antisense RNA 1 (head to head) GDNFOS[1]

Characteristics

GDNFOS gene has four exons that are spliced into different isoforms. GDNFOS1 and GDNFOS2 are long noncoding RNAs, and GDNFOS3 encodes a protein of 105 amino acids.[1]

Function

Dysregulation of human GDNF and DNSP-11 and GDNFOS may contribute vulnerability of AD pathogenesis.[1]

Expression

GDNFOS1 mRNA levels in human brain region and peripheral tissue[1].

The highest mRNA levels of GDNFOS1 are found in kidney, ovary, and testis, where GDNFOS1 mRNA is more than 10-fold of that of brain caudate region. further, higher expression is also observed in cerebellum and nucleus accumbens relative to other brain areas.[1]

Diseases

Middle Temporal Gyrus of Alzheimer Disease[1]

Sequence

>gi|1034643186|ref|XM_017008916.1| PREDICTED: Homo sapiens GDNF antisense RNA 1 (head to head) (GDNF-AS1), transcript variant X1, mRNA

000001 CAGGAGCGCA GGCTGGTCTT CTAGAGCCCG GGCTGGGGGT CCGGGGTCCG GGGTGGGGGA GGGGAGGCGC GGGGCCCCGG 000080
000081 GAGGGAGGGG TCGGGAGGCG TCGGCTGGGC CTGGCGGTGG GGGAGGAGAG GAGAGCAGCG AGGAGGCCCT GGAGTTCCCG 000160
000161 AGGCGGGGGG CCGGGGTGCG AGTGGGCGAC GCGAGGCGCC CCTCCCTGGG CTGCAGGGAG AGCGCTGAGA GCGCGGAGAC 000240
000241 GCCGCGGGGC TAGCGCCTTC TCCTCTCCGG GTGGATCAAA AATCGAGAGG AATGTGCGGC GCTCTGCGCG GGCCAGCCGA 000320
000321 AAGGGGCAAT CCGAACTTGA CCGCGGCGCC CGCGCCGGGC TTTGCCCCCG CGCGCCGCAC TGGGAGGGTG GCGCTCTGCC 000400
000401 GGTGCAGGGC AGCGCCGGGC TTTCCTCGCG CCTGTCGAAG GCCGGCCTTC CCGCTCGGGT GTCTCGCCCT CTCGCTTCTC 000480
000481 CGCAGGGCAG GAGGCAGTGG CGAGAAAAGG AGCTGCCGGC CGGAGTTCTA GCACCGAGAA GGAGAGGTGC GGAGCGGCCG 000560
000561 GGTGAGGGAA GCCGAGTATT TGCCAGGGGA CGCTGCGAGT GGGGATGAAT TTATAGGGCT CTCACTCCGT GACGTGCCCT 000640
000641 CCAGTGGCTT TTCTGATTCG CTTTCTGACC TAAACACACA TTAGTTTAGT CCCCATGCTA AGGCCAACAC GGTCTCCAAA 000720
000721 TATCTGCTGG CTGAAGTCAG AGGCTTTGCA TATCATGTAT TACATGGCAG GCAATGAAGA AGGCTTCTGA GGCTGGCCGG 000800
000801 CTCCTCAGTC CTAGGCTCCA TTTTCATGCT GTTGTAATCT AATACCAGAC ATGGGGCAGG CACATACATT CAAAATCCCA 000880
000881 ATTCCAGAGG CGTAAGATCA CTTTATCAGG AACGGGTTAG GGGAGGTTGA GCTAAACCTG CTTTTATCCA GATTTTCGAA 000960
000961 AATGCAGATG GGAAACTTCA GCAAGCGCCC ACTTGGATGC TGAGTTTCCA GCGATCAGGG GCCCGGCCCC CATTCCAGAG 001040
001041 CTCTGTGGAT GGGAGAGATG AGGACATTGA GGATCAGAGA TGTTGAAAAA CTTGCCCAAG GATGCACAAG TGGAATGTAC 001120
001121 TGGAATACCT GAGTTTTGGC TGGGCACAGA ACTGTCTGGA ATACAGACTG CAATTCCCAG CCTTCTGTGC AGTTCTGTGT 001200
001201 GGCCATGTGA CTAAGTTGTG GTCAATATGA GTCACGGAAG AATAGAAGAA CAACTCAGAG GAGGAAGAAG TCAGACATAG 001280
001281 CCAGACACGG CTGCTAGCAG TTCCACCAAT GAAAGAGGAG ACCAGGATGT TTAAAACAGG CAAACACAAG GTGCGAAAAA 001360
001361 CCAGAAGCGA AAACTTCTGA GGTCATTTAA GCAAGGACTA TCGTTATCCC CGGAAGCAGA GAGAAGTTCC CTTTGCCCAA 001440
001441 CATCACACTG CAAGCACGTG TTGGAGCTGA GATTCAAACC CAGGCATCCA GGGTCCAGGG CCCATGCTTT TAATATATTC 001520
001521 CATATCTTAG GAGAATTTCC CCTATTTAAA CAATAAAAGT GCAAAAATCT TGTGGCTAGC CAAAATTTTC AGTTGTTTGG 001600
001601 AAAACTTATT TATCCAATAA GTGGAAAACT CACTTGTCCT CCAACAATTC TGGATAAATG AAAGAACGAA TTGAACTGAG 001680
001681 ACTGGAATCC GGGTCTCCCA GTACTTTGTA GTTCCTATCC ATATGGCTTG TCAGGAAGGC CACAGGGAGG TTAACTAACT 001760
001761 CTGCGTAACC AGAAACAATC CCACATCAGA CTGTTGGCAG TGGGAGTGGA ACACTCAGAG CTGAACCGCA TGCAAGATGG 001840
001841 TTGCATTTTC ATTTGCAATG TCGTCATCTT CCTCATGGCT AAAGAGGTAT TTTGGAGTTG ACATGAAGGC TACTGTAATT 001920
001921 TTTAGAGGCA TTTTCTTTCT GGCCTGTATT TACATATTGT GGTAGAAGAG TCAGAAGACT TCAAGCTTCA AAAGTGAATC 002000
002001 TTGTTGCGAG TTACAAAAGC ACCACCCGGT GGGGTGCAGC TCTCAGCATG TGTCACCACA GGCACTGTGA TTTCCCTGTC 002080
002081 TTCATCCAAC TTTGGTTGCT GTTCTTCATG CTCAGGAATT CTGCAACTGC TGTAGCTTTT GCTGTTGTTA TGTCTGTAGG 002160
002161 TATGGACTCA TTTCTACCAT TCTGGAATGA AACATTATTT CAAGGGAAGC TTCTCATTGT AAAAGGTCCA CACATTCAGA 002240
002241 AGGAAACTGG GAGTACATTT TCTCATAGGC CTGGAGCATT AACTGACTAT GCATCTTTCC CCTCAGTGTT GTCATCATGT 002320
002321 TGTAAGGGGA TGAGTCATGG ACAACATTTT CACACACATA CGTGAGGTCC ATTGACCAGT CTTTAGGACA ACTAGAAATC 002400
002401 TTTTCTTTCT TTGTTTTAAA AAGGAAGACA AGTCAAGATA CAGCAAATAA AAATGCTCAG CACATTTGCT GAAATCTTAG 002480
002481 CAAAATCAAA

Labs working on this lncRNA

  • Neural Protection and Regeneration Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Social Services, Baltimore, Maryland21224, USA.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem. 2011 Dec 30;286(52):45093-102.