gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA
"TCONS_00011605, RP1-56L9.7-001, lnc-SOD2-1"
GCASPC is a long noncoding RNA and it is located within the intron of insulin-like growth factor 2 receptor (IGF2R). Subcellular fractionation analysis reveals GCASPC is mainly located in the cytoplasm of gallbladder cancer cells.
Compared with the non tumor tissues, GCASPC is down-regulated in gallbladder cancer tissues.
Gain and loss of function studies in gallbladder cancer cells shows that GCASPC can suppresses gallbladder cancer cell proliferation. GCASPC decreases the protein level and activity of PC by inhibiting its protein stability.
GCASPC can be directly targeted by miR-17-3p.
Labs working on this lncRNA
- Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China.
- Ma, M.Z., et al., Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer. Cancer Res, 2016. 76(18): p. 5361-71.