Approved symbol: FLVCR1-DT
Approved name: FLVCR1 divergent transcript
HGNC ID: HGNC:39077
Previous symbols: NCRNA00292; FLVCR1-AS1
Previous names: non-protein coding RNA 292; FLVCR1 antisense RNA 1 (non-protein coding); FLVCR1 antisense RNA 1; FLVCR1 antisense RNA 1 (head to head)
Alias symbols: LQK1
RefSeq ID: NR_027285
Ensembl ID: ENSG00000198468
GenBank accession number: AY030238 and AY030239
LncBook ID: https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0288978 HSALNT0288978]
FLVCR1-AS1 is a 2-exon gene and it appears to have arisen after duplication of the hFLVCR locus. FLVCR1-AS1 has two transcripts and both exon 2 isoforms share the same polyA signal.(Figure A )
FLVCR1-AS1 is expressed in a wide variety of tissues, including colon tumor, uterine tumor, placenta, lung tumor, brain tumor, neural tissue, fatal liver/spleen, bone marrow, aorta and kiney.(Figure C ) 
lncRNA FLVCR1‐AS1 was extremely up‐regulated in HCC tissues and cell lines. 
Both splice forms of the FLVCR1-AS1 cDNA encode identical 103 aa ORFs that include a 163 nt MER41D interspersed repeat. 
FLVCR1‐AS1 acted as a competitive endogenous RNAs to sponge miR‐513c which targeted the mRNA of MET for degradation. By directly sponging miR‐513c, FLVCR1‐AS1 increased MET expression in HCC, and then promoted HCC progression.
hepatocellular carcinoma 
Labs working on this lncRNA
- Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7710, USA. 
- Department of Pancreato-Biliary, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, P.R. China.
- Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. Gene. 2002 Mar 20;286(2):203-13.
- Zhang K, Zhao Z, Yu J, et al. LncRNA FLVCR1-AS1 acts as miR-513c sponge to modulate cancer cell proliferation, migration, and invasion in hepatocellular carcinoma[J]. J Cell Biochem, 2018, 119: 6045-6056.
>gi|224591396|ref|NR_027285.1| Homo sapiens FLVCR1 antisense RNA 1 (head to head) (FLVCR1-AS1), transcript variant 1, long non-coding RNA