FLICR:FOXP3 regulating long intergenic non-coding RNA 
Flicr neighbors Foxp3 in mouse and human genomes .
Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that regulates key transcription factor FoxP3 expression in Tregs, resulting in twofold- to fivefold-lower levels of FoxP3 protein . Flicr acts only in cis. It does not affect DNA methylation, but modifies chromatin accessibility in the conserved noncoding sequence 3 (CNS3)/Accessible region 5(AR5) region of Foxp3 . As a result, Flicr curtails Treg activity, markedly promotes autoimmune diabetes and, conversely, restrains antiviral responses . Also, this mechanism of FoxP3 control may allow escape from dominant Treg control during infection or cancer, at the cost of heightened autoimmunity .
IL-2 can repress Flicr to ienhance Foxp3 expression .
Flicr expression is also curtailed in conditions of heightened Treg activation and functionality .
Flicr is specifically expressed in Tregs .
autoimmune diabetes, antiviral response 
FLICR is highly conserved across mammalian species .
>NR_147988.1 Homo sapiens FOXP3 regulating long intergenic non-coding RNA (FLICR), long non-coding RNA
Labs working on this lncRNA
- Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.