FENDRR

From LncRNAWiki
Jump to: navigation, search

FENDRR

Contents

Annotated Information

Name

Decreased expression ofFENDRRin gastric cancer cells; histone deacetylation is involved inFENDRRdownregulation. [1].

FENDRR: FOXF1 adjacent non-coding developmental regulatory RNA .

Previous Name: "FOXF1 antisense RNA 1 (head to head)", FOXF1-AS1

ID

GenBank ID: KC505631.1

HGNC ID:49667

Characteristics

Chromosome location:16q24.1

Diseases

  • gastric cancer [1]

Function

FENDRR is essential for the development of many tissues and organs in mouse. It is found that FENDRR acts as modulator of chromatin signature by binding to both the PRC2 and TrxG/MLL complexes, and regulates heart and body wall development in mouse [2]. It is also involved in lung development. Deletion of FENDRR causes a lethal lung developmental disorder [3]. FENDRR(-/-) neonates of mouse show defects in lung, gastrointestinal tract, and heart [4].

FENDRR is dramatically downregulated in gastric cancer tissues and cell lines, and downregulation of FENDRR is significantly associated with invasion depth, tumor stage, lymphatic metastasis and patients'survival time. FENDRR may suppress gastric cancer cell migration and invasion by targeting FN1 and MMP2/MMP9 [1].

Expression

DNA methylation contribution little to FENDRR expression.[1]

Sequence

>gi|299890835|ref|NR_033925.1|:1-3099 Homo sapiens FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR), transcript variant 1, long non-coding RNA

000001 AGCAGACAGC GCGGGCTGGG AGCGCCGGCA AGGGCGGCCC TCGCGCACCT GGCTGCCAGC CCGCAGGGGG CTCGCACGCA 000080
000081 GACCTGCCCT TGCCACCTCA GCGCTCGGGT GCGGGCTGGG GGCGGTGGAG CCACGAAAGG TGGTGCCGAG AGCGGAGCGC 000160
000161 AGGACAGCGC AGGAGCCCCG GCGCATCGCG GCGCGCACAG ACCCAGGATT ACTTCATGCA CATAAAAGAA AACGCAACTA 000240
000241 CAGTGGACCC TGAACAACCT ATGGCCTGCA GCCACTGAAG AATGCTTGCA TAAGGAGCTC TTCTCTGCAC ATACCCCGAC 000320
000321 ACAGTGATGG TATCTTGCAG CTGCTGCTTC TGTCCAAGGC ACTGCAGCCT ACTCGTCAAA AGCCCGAAGC CCAGCTCTGC 000400
000401 CAGCAGTGCA CTGTGTGCTC TTAGGAAACA GAGAAGCAAA GAAGTTAGCA AGCTTGTTTT GGCAGAAGAA AAAACACAAA 000480
000481 ATACCCAACC ACAGATCCTC AAAAATATTG CTAAGCACTA ATTTTGCTAA CATGTTAGAC AGCCTTCGGA TCTAGGCAAT 000560
000561 CTTGTTCCTC AGCTGGAAAG AGTTCCTGCC AGCCATGTGA TTCCAAATCC ACCCTGGACA TATGGGGATA ATGAGAAAAT 000640
000641 CAGCTCCGGC CTTCCCTGGC CTTCCAGCCA AGTGAATGGG GGCATCCCCT GGTGCTTCAG CCCGGGGCCC ACCCAGAGGA 000720
000721 TGCTAGCTGG CCTGCAGAGG CCTCAACCAT GCCCTCCTGG ACTCAGGTAA GACTGAGGTT TCCATGCCCT CAAAACAATT 000800
000801 GTTCAGACAA AAACTCACTG CCCAGGTCAA AGTCACAGCA CCAGAAAGCC AACCTGAGGA TGAAGACAAA GCTCTTTGTT 000880
000881 GGCACAGTCC CCTGATCATT CGAGGTCAGC ATCTCCATCA AAATGGACCC AATGCTGAGG CAAGAAGGAG AACATCACTG 000960
000961 TTAAGAAGGT AATGAGTCAC AAATGCTATT TCGATGGTTT TCTTTGAAAG AAATACACAG AACCAAACCA ATTTTAATTA 001040
001041 AAGATCTTGT CTTTGTAATC AGGCAGCCAC AAATGAAGGC AAAACTGCTT TCATGTGGCA TAATATACAC AGAGCTGAAC 001120
001121 TAGTTTTCCC ATAAAAGGGC AGGTTCTTTT CTTCAAATAA GAAAAGAGTT TGTTCCTAAC AATATGGGGG ATGCAACAGA 001200
001201 AAGCTGTCTT TTGCAAAGTA TAAAATTGCA GATCCTCCCG TGGAAGCCAT TTCTTGATGC TAAACCAATG CGAACGTTTG 001280
001281 CCAAACGCAC ATGCGAGCCG GGATTATCCT ACCCTTTGAG ATTAGACATG TGATCCTGAT TTTTAAGTGA AAAACGCAGC 001360
001361 CAGAGGCCAA ATAAACATAC CTACAAGTAC ATCGAAAGCT CAAATGGTTG AGAAATGATT GTAACACACC CCGGTGTGTA 001440
001441 TTTCTGAGGA AGAATCAACA TGCACATGGA AATTGATGTT TTGATTTTTA ATTTTAAAAC GACGACAGAA CTGAAATACC 001520
001521 TCCCCTAACT AGGTCCACTG AAACCAGTGA GGAGATAATC ATTTTCAGTT AAATATGCAT GTAATTTAAT AATCCACAGA 001600
001601 TGGAAAATGC ATTTGAGGTG GACTGAACAC AGCCAGGAGT TTTTGCTTAT CGACAGCACT GAATCCTGCC TTGACTAGAG 001680
001681 AGACTCGTCA TGTGATCAAC TGTGGCCAGA GGGCATCCTG CAGACAGCTC CTGTCACACC ACACTGACCA GACTCTTATG 001760
001761 AGTATTTAAG CATCTTCAGG GAAGCGATTG ACTGTCTTAT AATGGTCTTA CAAGTACGGA ACTTTATTAC CTGCTAATAA 001840
001841 TCAGAGCACA TGATGGCACA ATAGAATATA CGAGTGAAGT TCTAAATGCA AGGTTGTTCT TATTCTGTGA GTGGCAAAAC 001920
001921 TCATGCAGTG AGCAGATAAA GCTGGCAGGA GGCATTGGCG CCCTAATGCT GGGCACTAAC CACCTGCCCG GACTGCGAAT 002000
002001 ATCTGTTGGG TCCTTTCTAT ATCTGGTCTA TTCTCGTGTT TGATTATATC CTGGTGGCAA GAATAGCAAA ATCAACTCTC 002080
002081 CTTCCTATCC CATGTGGAGA GGCATGATTT GAGTCAGAGA GCATTATCCT CTCTGCGTTA TCCAACCCCA TGTCCCATGA 002160
002161 TGCACTTTGT AGACAAGCAA GTGTCCCTGG TGGAGAATCC ACAGCCACAC ATCCTCATTG GTTGCAAGGA TCAGTGTCCA 002240
002241 ATATCTACTG CCATGATCAT TCTCAGTTTT ACATCCACAG AGCTTCATAG AATTCTAACA CCACAGGTCC AAGTAGAGGT 002320
002321 TTTGGCCTCA GAGTGGGCTA GATTCCACCT CTGACAGCAG CTGTGGGACT GTTTTTCCAT CTGTAAAATG GAGACAAGAG 002400
002401 TATCACCTAC CTCATGGTGT TGGTGGGATC GTTAAACAGA ATTCCGATCA TGAAACCCTT AGCCTGCTCC CTGCATAGGC 002480
002481 TGCATGCGCT CAGTGAGCTA TGGCTCTGTT TCATGCTGAC TTTACCATCA TGTAAGCAGT TTTAAAAATG CTAGAAGCTT 002560
002561 TAGTCATAGA ATTACCATAT GATACAGCCT ACTGCAGAGT CCAGAGGCTG AGGCAGGAGA GTTACTTGAA CCTGGGAGGC 002640
002641 GGAGGTTGCA GTGAGCCAAG ATCGCGCCAC TGCACTCCAG CCTGGGCAAC AGAGTGAGAT TCTGTCTCAA CACAAAAAAG 002720
002721 AAGACATGTG TCCCCATCAC AGTATCATAC AGAGTGCTTC CACTGCCCTA AAATACCCTG TGCTCTTCCT ATTCATCCCT 002800
002801 CTCTTCAACC CCAGCAACCA CTGATCCTTT TACCATCTCC ATGGTTTTGC CTTTCCCAGA ATGTCATATT GTTGGAATCA 002880
002881 TACGCTATGT AGCCTTTGCA AATGGGCTTC TTTCACCGAG CAATGTGCAT TGAAGGTGCC TCTATGACTT TTCAAGGGTT 002960
002961 GATAGCTCAT TCCTTTTTAT TGCTAAATAA TATTCCATTG TCTGAATGTA CCACATTTTG TTTATCCATT CACCTACTAA 003040
003041 AGGACATCTT GGTTGCTTCC AAGTTTGGGC AATTATAAAT AAAACTGCTA TAAACATTG

>>gi|301897529|ref|NR_036444.1|:1-2693 Homo sapiens FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR), transcript variant 2, long non-coding RNA

000001 AGCAGACAGC GCGGGCTGGG AGCGCCGGCA AGGGCGGCCC TCGCGCACCT GGCTGCCAGC CCGCAGGGGG CTCGCACGCA 000080
000081 GACCTGCCCT TGCCACCTCA GCGCTCGGGT GCGGGCTGGG GGCGGTGGAG CCACGAAAGG TGGTGCCGAG AGCGGAGCGC 000160
000161 AGGACAGCGC AGGAGCCCCG GCGCATCGCG GCGCGCACAG ACCCAGGATT TGTGAAGAGG TGACCCAAAT TTCAAGACAA 000240
000241 TGTTGGATGC AAACGGATTT GCCAGCAACT GCATCACTGT CAAAACCAGC TCTGCCCGTG TCTTCCGAAG ATACCAAGTG 000320
000321 AAATACATGT AGATGGGATT TACATCTGAA AAACCAAGTG AGAAACTGAA GACCAGAGAG GGTGAGTGGT TTACTCAGTT 000400
000401 TGGCACAACT GACCCCAACC TAGCCCTCCA TGAGGACTGA GCGCATGAGA GATCCTGAGC CACAGCCGCC CAGCCCTGCT 000480
000481 CCTCTCGAAT TTCTGACCTA CAGGAACTGC AAGAAGTAAT GAAAGACTGC TGTTTAAAGC CACTGCATTT TGGCATGATT 000560
000561 TGTTATGCAG TCGTAGATAA CCAGAAAACA TCGGATTTAC ATTTTAAGGA TTTGGTGCAT GGGATGGGCT CAGTTGGGCA 000640
000641 GTTCTTCTGT TCCATGTGAT GGTACTGGGG CTGCAGTCAT TCAGAGGCTC AACTGGGCTG AACGTGCAAG GTTTCTTGCT 000720
000721 CACGTGGCCA TCAGTGGTGC TGGCTGCTGT TGGGAGCTCC ACTGGACTTC TGTCCAGAGC TCCTCAGCTC ACCTCTCTGT 000800
000801 ATCCTTGCCC TGTGGCTCAG GCTTCTAACA ATACAGAGGC TGGATTCCAA GAGGAGGGAA TTAGAAGCGT TCAGCCTTCT 000880
000881 TAAGACCAGG ATTCAGATGT CCCAGACTGT CACTGTATTG ACCGGAGCAT TTACAGGCCA GCCTAGTAAT TTTTCCATCT 000960
000961 TGGGCAGGAA TGGGTGGCAT ATGCTGGGGG TAGGGGTAGC ATTGTTGGGG ATCATCTTTG GAGCTGTGTG CCAAGGAGTA 001040
001041 AATTGCTGGG CTGCTTTCTA CCTGAGGAAG TCCACTATGC TTGCTTGTGG AGAGTGGATT GTGTGCTCAG AGTCCACAAG 001120
001121 GATTTAAGAA TCCGAGCCCT GCTGCCCTTG CCTCAGCCTG TGCATTAGGG CCCGGTGGTG AGAGCACTGA GCCATTGTGA 001200
001201 ATCAAGGCCC CTCCCTCGAC CTGCATACTA ACAGGCCAGA AGAGCTTGCT TGATTTTGGT CCTAGGCTCC TGCCTGTGGG 001280
001281 TTGGATTCCA GGGGCACTCT CTCCTCCACA AACCAGACGG TGGCAGGTAC ATCCCCTCAA TGGAAATTGC CCACACTTCA 001360
001361 CCCTAAAGAC AGATCCTGCT GTTCAGCAAC AATGTGAGTG GCCCACACAT TTGTCCAGCA TGAAACCGTT TGCAGATTCC 001440
001441 TTTCCAGTAC ACAGTCCCGT CAGCCGGTCA CTTCACGATG ACAGCTCCTC GAAGCACCTT TTGGTTTGCA GTTGTGTAGC 001520
001521 TTAGAAGTAG GAGCCTGCAC GGCTTCAGGA ATTCACAGAA GGAGCACACT TTGTGCTTGG AGAAGTTAAT TATAGGAATA 001600
001601 TCCTGCAACC TGCTGCTCTG AGCCTGTGCA CCTGGGGTGT TTCCCTGGAG GTCCTGTGTA TGAGGATACT CATCAGCATG 001680
001681 GGGTTTGGGA AGCCTAGCAG TGGAGACAAC CTAGGTGGTC CTCTCCAGGG GAGTAGGTAA GAGCCCTACA GCAGTGAAAA 001760
001761 GCATTGAAGG AAAAGTGTGT TCAGCAGTGC TCTTAATCTG ATCAGAGCAG CCTGAACACA TTCTAAACAC AGGGCATTTA 001840
001841 GAACTAGGGT AGAGGCACTA GAGCACCATA GATACAAACT CAGATTCTGA AGGTAAATGC CCAGGTTCAA ATCCAAGCCC 001920
001921 CCTCGCCAAG TGACCATGAC TCCCCCGAGT CACCTGACCT CTGTGTTTAC ATCCTCAAAG TTAAGTAGTC AGGAAAGGGG 002000
002001 GCTTGGGGCT TGCCACATGG ATGGTTGCCA CTCTCCTTTG CAAAGTGTAG TCCCCAAAAA CAGGTGGAAG AGGGAAGGGT 002080
002081 CCAATTAGAA GGCCGAGTAC CAGCTGCCAT GAATATGCCA GAGCTGCTGG CTAGTGATAA ATAACTGAAA CCCAGGGGGA 002160
002161 CAGCAGAGCT TGGGTGACCA TACATTCTAG GAAAGAAAAC ATGCCTGTTG TCCTGGCTTT TTATCCAGCT TAGACAAAGA 002240
002241 TGGGCAAAGA AAATAATTTA GAAAATGGTA GAGATGGGCA CAGAGAAAGG GCACGGAGGG AGGCACAAAC AGAAGGCCAA 002320
002321 GTGATGGTGG AGGCAGACAT TGGAGAAATG CCTTTACAAG CCGGGGAATG CCAAGGATGC TGGCAACCCT GGGAGTGGGA 002400
002401 AGAACCTGGA ACACACCCTC CGTCAGAGTC TCCAGAAGGA ACTGGCCCTT CATCACCTTT CGGACTTCTG GCCTCCAGAA 002480
002481 CTGGGCAAGA AAATGTTTCT GCTGTTGGAG GCCATCCAGC TGGTGGTCAT TTGTTATGGT TGCCACAGAA AACGAATATA 002560
002561 GATTTAGACA TCTAATTTGC ATATATAGAT ATGCATGTGT ATTTGTTAAA TAAAAGATAA AGCATGACAA CTCGATGGAC 002640
002641 AACGTTACAA CTCATTAAAT TGTGTTGGTT AAAAAAAAAA AAAAAAAAAA AAA

References

  1. 1.0 1.1 1.2 1.3 Xu, T. P., M. D. Huang, R. Xia, X. X. Liu, M. Sun, L. Yin, W. M. Chen, L. Han, E. B. Zhang, R. Kong, W. De, and Y. Q. Shu. "Decreased Expression of the Long Non-Coding Rna Fendrr Is Associated with Poor Prognosis in Gastric Cancer and Fendrr Regulates Gastric Cancer Cell Metastasis by Affecting Fibronectin1 Expression." J Hematol Oncol 7, (2014): 63.
  2. Grote, P., L. Wittler, D. Hendrix, F. Koch, S. Wahrisch, A. Beisaw, K. Macura, G. Blass, M. Kellis, M. Werber, and B. G. Herrmann. "The Tissue-Specific Lncrna Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse." Dev Cell 24, no. 2 (2013): 206-14.
  3. Szafranski, P., Dharmadhikari, A.V., Brosens, E., Gurha, P., Kolodziejska, K.E., Zhishuo, O., Dittwald, P., Majewski, T., Mohan, K.N., Chen, B. et al. (2013) Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. Genome Res, 23, 23-33.
  4. Sauvageau, M., Goff, L.A., Lodato, S., Bonev, B., Groff, A.F., Gerhardinger, C., Sanchez-Gomez, D.B., Hacisuleyman, E., Li, E., Spence, M. et al. (2014) Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife, 2, e01749.
Personal tools
Namespaces

Variants
Actions
Navigation
About
ScienceWikis
Toolbox