ETS1-AS1

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ETS1-AS1, a novel lncRNA associated with the gastric cancer progression.

Annotated Information

Name

ETS1-AS1: ETS1 antisense RNA 1 (HGNC:53932)

Alias

pancEts-1: Ets-1 promoter-associated noncoding RNA

Characteristics

pancEts-1 is a lncRNA associated with poor survival of gastric cancer. Scheme indicating the existence of pancEts-1 transcribed upstream the Ets-1 promoter region. [1].

Ets-1 promoter-associated noncoding RNA (pancEts-1) is a novel 1395-nt lncRNA consisting of four exons and is polyadenylated. It is associated with poor survival of gastric cancer. It targets the promoter region of Ets-1 at chromosome 11q24.3. Northern blot analysis confirmed the existence of 1.3-kb pancEts-1 transcript in MKN-45 cells. [1]

Function

pancEts-1 facilitates the physical interaction between NONO protein and Ets related gene (ERG), resulting in increased ERG transactivation and transcription of Ets-1 associated with gastric cancer progression. In addition, pancEts-1 facilitates the growth and aggressiveness of gastric cancer cells via interacting with NONO. [1]

Regulation

In gastric cancer tissues, pancEts-1 was upregulated and significantly correlated with Ets-1 levels. [1]

Expression

High pancEts-1 expression in gastric cancer patients was associated with poor survival.[1]

Diseases

Gastric cancer [1]

Labs working on this lncRNA

  • Department of Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022 Wuhan, Hubei Province China
  • Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022 Wuhan, Hubei Province China
  • Clinical Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022 Wuhan, Hubei Province China

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Li D, Chen Y, Mei H, Jiao W, Song H, Ye L et al. Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression[J]. Oncogene. 2018, 37(35):4871-4886.

Sequence

>gi|101929517|ref|NR_120581.1| Homo sapiens ETS1 antisense RNA 1 (ETS1-AS1), long non-coding RNA

000001 GTCAGGAGGG AAGAAGGGAG GGTGGGGTGG GGTTGGGGGA GAGGGGAGGA CTTGGGAGCC TGTTTGCCCT GGAAAGCTCA 000080
000081 ATATAAGAAA ACAAAGAGGA TAGTAGTGTG GGCTTTGGAA TAAGACTCAG GTTCAAATTC TTACTCTACC AACTAGCCAG 000160
000161 CTGAATTGCC ACAGCCATCT CTTTGCAGAA TAGCTTGGAT GCTCAATTTT CCTGAACGAT CTCCAGCGAG AGATAGAACA 000240
000241 ACTATCACCA CATTTCATTT AAAAATCTCT TCAAGACCCT TCCTCAGTTC TTAAACTGGC AACCTGCCCA GCATCAGCCT 000320
000321 CACTTGAGAA ATTCGAGAAC TACCTGATTG GAGAAGAGAA CTAGATTTAT ATTTGTTTTG AGTCACAGAA AAGTGACAGT 000400
000401 TTAAATTCTG AAAGAAGATC ACATTTGTAG TGCCTCTTTG GAGACAAAAC CTTAGGTCTT GGATTTGTCA CATGTTAGAG 000480
000481 CTCAATGGGA GTTTATCAGT GCTCTCCAAG TCCAGCACTC CTATTTACCA GAGGTGAAAA ATGAGTGTGA GTGAGGAAAT 000560
000561 TATTATTTCC AGGGCCACAC AATCTAAAAA AGTCAGTGTC AGTACTAGAA CCAGATGCCC TGATAGCAGT TCTCTCCCTG 000640
000641 GCATCTCCTT GCATTTACTT TGCATTTCAC TTTGGCAGGA GAAGTACCAG ACACCCTTGA GACACAAGAC AGGATACAAT 000720
000721 GGACATGGGA GTAGATAGAT GAGCAGACTC AATTTCTAGA AATCCAACTT CTCTACACTG GATGTATTGT CTTTGGGCAA 000800
000801 ATACATTGCA GGATAACCAC ACTATGGTTC CCTGTGGGAG ACAGCTTGGC ATGGGCTGTC AGGAGAGAAA GGGCCTGGGT 000880
000881 TGGCTCTATT GCTGTCTGCA GTTTCTTTAG ACTATAATTA TGAACCATTC AACTGCATCT GCAGCCCCAA CAATGTGGGG 000960
000961 TGGATTGGCC TAATCCACAG ACCAAGCGAC ATTTTAAAAT CCAGCAGTTT AGACACGTAT TCCTCTTGCA GCAAATCAAA 001040
001041 CATGGCTCAG ACAGGAAGAG ATGGCTGCTC AGAAGCAGTC TTCAGGAATT TCCGAACTTC GAGTTGAATC TTTTATTTCA 001120
001121 CTGGCTTCCA CAAAGCGTTA CAGCTCACAT TTGATTCTCA GCTCTTAAGG ACCAAAAAGA AATGAAGTCT TCTTTAATTT 001200
001201 GCAAGCAGCC AGCTGTGCTC ACTCCACATC TTGCATCAGC CCTGTGAAGG AGTCAGAATG TAGTGGATGG TCCTGCCCAT 001280
001281 GACTCATGAG GTGGAACAGA CCCAGCTCAC ATCTCATCTA TCTGGATTGG CTCCCATACA ATAAAAATCT TTCTTCCGTT 001360
001361 GAGTTGGTGA AAAGAAGAGA AAAAAAAAAA AAAAA