Approved Symbol: EPB41L4A-AS1
Approved Name: EPB41L4A antisense RNA 1
Previous Symbols: C5orf26, NCRNA00219
RefSeq ID: NR_015370
Ensembl ID: ENSG00000224032
LncBook transcript ID: HSALNT0288958
Pubmed IDs: 9490301, 30796006
- EPB41L4A-AS1 could alter glycolysis and glutaminolysis levels of cancer cells. Furthermore, EPB41L4A-AS1 knockdown plus glutaminase inhibitor suppressed tumor progression both in vitro and in vivo. Mechanistically, EPB41L4AAS1 interacted and colocalized with HDAC2 and NPM1 in the nucleolus, controlling HDAC2 occupation and H3k27ac modification levels on VHL and VDAC1 promoter regions and regulating their expression, which affected glycolysis and glutaminolysis.
EPB41L4A-AS1 expression was transcriptionally regulated by p53 and PGC-1α.
EPB41L4A-AS1 is down-regulated in some human cancers. The low expression of EPB41L4AAS1 was associated with poor survival in several cancer types, including cervix, liver, breast, bladder and other cancers.
>gi|284005302|ref|NR_015370.2| Homo sapiens EPB41L4A antisense RNA 1 (EPB41L4A-AS1), long non-coding RNA
Labs working on this lncRNA
- School of Life Sciences, Tsinghua University, Beijing 100084, PR China
- Liao M, Liao W, Xu N, et al. LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2[J]. EBioMedicine, 2019, 41: 200-213.