ENST00000602580.1

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MIR99AHG, the human miR-99a/100 ~ 125b cluster host genes, resides in the nuclear cell compartment, where it plays a role in the regulation of erythro-megakaryocytic development.

Contents

Annotated Information

Name

MIR99AHG: mir-99a-let-7c cluster host gene(HGNC nomenclature)

"megakaryocytic oncogenic non-coding RNA", MONC[1]

Characteristics

MIR99AHG 5 spans ~ 500 kb and is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs.Exons 3, 6, 7, and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible tran-script is ~ 1300 bp, with the only significant open reading frame (> 100 amino acids) located in exons 1 and 2. If this indeed represents a translated product, it implies MIR99AHG has an unusual 3’ UTR composed of ~ 9 exons[2].

Cellular Localization

MIR99HG is localized in the nucleus and their expression correlated with the corresponding miRNA clusters[1].

Function

LncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia[1]. In AMKL they contribute to the maintenance of leukemic growth[1].

Disease

  • myeloid leukemia

Expression

LncRNAs MONC and MIR100HG are highly expressed in AMKL(acute megakaryoblastic leukemia) blasts[1].

MONC is ubiquitously expressed at reasonably high levels and is conserved in mouse ESTs[2].

Labs working on this lncRNA

  • Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany[1]
  • Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA. [1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D, Klusmann JH. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia[J]. Molecular cancer. 2014,13:171.
  2. 2.0 2.1 Gardiner K, Slavov D, Bechtel L, Davisson M. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis[J]. Genomics. 2002,79(6):833-43.
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