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MIR99AHG, the human miR-99a/100 ~ 125b cluster host genes, resides in the nuclear cell compartment, where it plays a role in the regulation of erythro-megakaryocytic development.


Annotated Information


MIR99AHG: mir-99a-let-7c cluster host gene(HGNC nomenclature)

"megakaryocytic oncogenic non-coding RNA", MONC[1]


MIR99AHG 5 spans ~ 500 kb and is composed of at least 11 exons, of which only 3 are consistently predicted by coding exon-prediction programs.Exons 3, 6, 7, and 10 are alternatively spliced, suggesting multiple transcripts can be produced. The longest possible tran-script is ~ 1300 bp, with the only significant open reading frame (> 100 amino acids) located in exons 1 and 2. If this indeed represents a translated product, it implies MIR99AHG has an unusual 3’ UTR composed of ~ 9 exons[2].

Cellular Localization

MIR99HG is localized in the nucleus and their expression correlated with the corresponding miRNA clusters[1].


LncRNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia[1]. In AMKL they contribute to the maintenance of leukemic growth[1].


  • myeloid leukemia [1]


LncRNAs MONC and MIR100HG are highly expressed in AMKL(acute megakaryoblastic leukemia) blasts[1].

MONC is ubiquitously expressed at reasonably high levels and is conserved in mouse ESTs[2].

Labs working on this lncRNA

  • Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany[1]
  • Eleanor Roosevelt Institute, 1899 Gaylord Street, Denver, CO 80206, USA. [1]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D, Klusmann JH. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia[J]. Molecular cancer. 2014,13:171.
  2. 2.0 2.1 Gardiner K, Slavov D, Bechtel L, Davisson M. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis[J]. Genomics. 2002,79(6):833-43.
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