ENST00000602507.1

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Please cite: Chunlei Yu (2016) lncRNA: "ENST00000602507.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000602507.1&oldid=1272308 (Last update: Jul 01, 2016). [See details]

MIR222HG, which was located on Xp11.3 and interacts with miR-222 and miR-221, is up-regulated by Ang II and functions in promoting cell growth.

Contents

Annotated Information

Name

MIR222HG: MIR222 host gene(HGNC nomenclature)

Lnc-Ang362[1]

Characteristics

MIR222HG, located on Xp11.3, is proximal to two miRNAs, miR-222 and miR-221, which have been previously associated with regulating VSMC proliferation and Ang II actions in endothelial cells[1].

Disease

Ang II-associated cardiovascular disease

Function

Since miR-222 and miR-221 are known to play a role in proliferation of VSMCs (vascular smooth muscle cells), MIR222HG functioning in cell proliferation may likely be through its role as the host transcript for the two miRNAs[1].

MIR222HG may be conserved in human and mice as modification of H3K4me3 is not enriched at the locus encoding for miR-222/miR-221but is enriched ~25kb upstream from them[1].

Regulation

MIR222HG was up-regulated by Ang II[1].

Expression

The pool of siRNA oligos for targeting MIR222HG are as follows,

Forward Reverse
5'–TTTCTCTGTACAAATGTCAUU-3' 5'-TGACATTTGTACAGAGAAAUU-3'[1]
5'-UUUCUGCCAUGACAUUUACUU-3' 5'-GUAAAUGUCAUGGCAGAAAUU-3'[1]
5'-UAAGCAGAUGAAUUCUAACUU-3' 5'- GUUAGAAUUCAUCUGCUUAUU-3'[1]
5'-TTTATTTGTCAGAACCTTTUU-3' 5'-AAAGGTTCTGACAAATAAAUU-3'[1]
5'-TATTTCTCTGATAAAGCATUU-3' 5'-ATGCTTTATCAGAGAAATAUU-3'[1]


Labs working on this lncRNA

  • Department of Diabetes, City of Hope, Duarte, CA, 91010[1]

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Leung A, Trac C, Jin W, Lanting L, Akbany A, Saetrom P, et al. Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells[J]. Circulation research. 2013,113(3):266-78.

Basic Information

Transcript ID

ENST00000602507.1

Source

Gencode19

Same with

NONHSAT136809, MIR222HG, Lnc-Ang362

Classification

intergenic

Length

1758 nt

Genomic location

chrX-:45627783..45629672

Exon number

2

Exons

45627783..45629355,45629488..45629672

Genome context

Sequence
000001 CCACTCTCCT GCCTGGGCTG CTGCTCAACG GGGGCTGGGG GTGTGTGGGG CGGGGGTGGT CTGTCCAGTG ATTCAGCCAC 000080
000081 ATGTGATAGA TGACCAAGTG ACTGCTTTCT TGGAGTCCGC ACACCAGTGG AAGACTCTCA AAGTGGTTGT GACCGACTTG 000160
000161 ATCAAACTCT AGGCTTCCTG AACTGGAATG AAATGCAGAT AACTCTTTAG AAAACTTTTG TAGGAAAAGC GCCTCGTGTG 000240
000241 ATCTGGAACA AAGACGTTTT ATAATCAGAT TTATCAAGCT GCGAAGAGGG AGTTTTAGTG AACGGAAGCA GCAGCATTCT 000320
000321 GTCACCAGGA AATACTCCTT TATCCAGAAT TGGTAAGTGA AAAGTGGCAT TGCTCCCTAA TAGATATCAT ATGCGTGTGT 000400
000401 GGGAATTGAA AAATTGTTCA CAGACCCCTA ACAACTGTGT TGAACAGAGA ACACATAAAC AGTGAGGAGT TCTAAAAAAG 000480
000481 AGCAGCACGA GAATACCGCA TAAAGACTGA GAAGAAGCCA GGTAATTAAC AAAAATGAGC TGAGTGCTAT CAGTTTAGCT 000560
000561 AAACATATGT AATACAGCTA GATTTGGTTG TTTTATTTTT TCTTGTTAGT GGAGGAGAAA CATAAAATCA GAATGGGCTG 000640
000641 TTTAGTAGAA TTGCGACATT AACTTTCCAT GGATGTAGAT TTCCATTTAG TCTGAATAGC ATGTATGAAA TTTGAAGGGA 000720
000721 TGCTTTCAGA ATTAGTCTAC TTGCCCTCCT TTCCTTTCCT CTGCATTAAG ATGTCAAGTA TTTAGTTAGA ACCTTACAAG 000800
000801 ATGAAAGTTG TACAAAATGA AAGTTCAAGT AATGCGTCGG AAACACCTCT CCTGATTGGG AAGGGTAGAT TACAATGGCA 000880
000881 ATAGATTTTT GTTTTTTGTT TCTTACATTT GTGTCACGAA TTTTAAGTTT GTTCTATTGG ATTACATTAG TACAGCAAAA 000960
000961 GGGGGGTTAT TTCTATCTAT ATGGTTCATG ACATTTTGAG AGGTCGTGAT TAGTAGTTCT TACTGGTTTC GTATGCGTGT 001040
001041 TCCTGCCTGT TGAATTCAGT TTTCTAATCT TGAATCTGAG CTGCCTTTAT GTTAAAGGGT TCTAGAAAAA GACAATAAAG 001120
001121 CTTTGAATAC CCGTGTTATA TACAACAGGT TCCTGTTCAT GATGTATAAG GTAACGCAAT TTTATTTTAG GCATGAATGT 001200
001201 CTAATTTCTT GATTTGGCTT CTTAAGAATA TACTGAAAAG GTTGAATAGA ATAAGAAAAA GAACATTAGA AAAGAATGGT 001280
001281 GGGTGACTGC CTGATTTTAC TAGTTTCTTA TTGGTCAATA GAAGTAATCA TGTGATGTCT ACTTATAGAA GCAAATGGAA 001360
001361 AAAATTTTTC TTCTTTAACT GCTAACAAGT ATATAGGCAA TTTTAGCAAT CTTCATTTAT TAATTTGAAT ATATAATTAT 001440
001441 AACTGTTATT AACAGAATAA GTTTTGGGTA ATATAGGAAA TAATAATTAT TTCTTTCTTT TTAAGCCAAA TTGGAAGTTG 001520
001521 AATCTACTTT TGGTTCCTGT TCTGTTACTT TCAAAATCTT AAAATCCTTA ACTCAAAAGG GAAAATGTAT AATAAAACAG 001600
001601 GATAGCAGTG CTGAAATTTC TCTCTCTTAG CAGTGGAGTG GGATGAGGGT GGGGGAGGGA GATGAATCTA GTGAGATATA 001680
001681 TTAATTGTTT TTTCCCCCTC TTGTATACTT GGATAACTTT TGAGATCAGT TTTCTCAGAC TAGCAGCTCT CAAGACTT
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Please cite: Chunlei Yu (2016) lncRNA: "ENST00000602507.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000602507.1&oldid=1272308 (Last update: Jul 01, 2016).
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Chunlei Yu1.648116520.9982016-06-25 14:31:33[show]
Contributors with score < 1 are excluded from the authorship.
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Lin Liu0.05615612016-07-01 20:26:13[show]
Note: For each edit version that is contributed by a specific person, his/her contribution is quantified as its edit quality multiplied by its edit quantity; the edit quantity amounts to the edit distance in comparsion with its previous version (that is, the minimum number of edit operations required to transform one string into the other), and the edit quality corresponds to whether the edit persists in comparison with the last version, ranging from -1, when the edit is entirely reverted (short-lived), to 1, indicating that the edit is totally preserved in the last version (long-lived). Please also note that contribution quantification may take time to reflect recent edits.
*Since one person may perform many discontinuous edits for a wiki page, contribution score is the sum of quantified contributions over all participated edits.
#Multiple successive edits provided by a researcher are counted as one edit.
ΛSummed edit quantity is the sum of edit quantities over all participated edits.
Averaged edit quality is the edit quality normalized over all participated edits.
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