PCAT1, a novel prostate cancer ncRNA alternately demonstrating either repression by PRC2 or an active role in promoting cell proliferation through transcriptional regulation of target genes.
PCAT1:prostate cancer associated transcript 1 (non-protein coding)(HGNC nomenclature)
PCAT-1 resides in the 8q24 “gene desert” locus. PCAT-1 is located in the chromosome 8q24 gene desert approximately 725 kb upstream of the c-MYConcogene.
PCAT-1 biology may exhibit two distinct modalities: one in which PRC2 represses PCAT-1 and a second in which active PCAT-1 promotes cell proliferation. PCAT-1 and PRC2 may therefore characterize distinct subsets of prostate cancer.
PCAT-1 can stratify overall survival and correlated with distant metastasis in CRC patients, and the prognosis of CRC may be influenced by PCAT-1 expression, which suggested that PCAT-1 may be a potential diagnostic target in patients with colorectal cancer.
PCAT-1 was regulated by PRC2 complex in prostate cancer cells.
PCAT-1, which is markedly overexpressed in a subset of prostate cancers, particularly metastases, and may contribute to cell proliferation in these tumors
PCAT-1 was overexpressed in colorectal cancer.
siRNA sequences (in sense format) were as follows:
Labs working on this lncRNA
- Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
- State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Prensner JR, Iyer MK, Balbin OA, Dhanasekaran SM, Cao Q, Brenner JC, et al. Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression[J]. Nature biotechnology. 2011,29(8):742-9.
- ↑ 2.0 2.1 2.2 2.3 2.4 Ge X, Chen Y, Liao X, Liu D, Li F, Ruan H, et al. Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer[J]. Medical oncology. 2013,30(2):588.