ENST00000556013.2

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PTCSC3,shorted for papillary thyroid carcinoma susceptibility candidate 3,is involved in Papillary thyroid carcinoma.

Contents

Annotated Information

Name

PTCSC3:papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)(HGNC nomenclature)

Characteristics

PTCSC3,a 1152 bp thyroid-specific lincRNA gene (PTCSC3), located in a linkage disequilibrium block with a GWAS-derived SNP (rs944289).

Function

PTCSC3 expression is highly thyroid specific suggests that it is involved in thyroid function[1].

PTCSC3 expression is significantly down-regulated in tumor compared with unaffected thyroid tissue, and the risk allele is associated with significantly stronger suppression of PTCSC3. The restoration of PTCSC3 expression in PTC cell line affects genes involved in thyroid tumorigenesis and inhibits cell growth[1].

rs944289 predisposes to PTC by dysregulating the expression of PTCSC3, which acts as a tumor suppressor[1].

Diseases

  • Papillary thyroid carcinoma (PTC)[1]

PubmedID

22586128

Expression

PTCSC3 is almost uniquely expressed in thyroid tissue with very low expression additionally in kidney tissue[1].

The cDNA of PTCSC3 was amplified by PCR,

Primer Forward Reverse
PTCSC3 5'-gtacggtaccCTCCTTCAGACTTCTCAGTACTC-3' 5'-tcgactcgagATTGCTACTGTGAGCATAACCTAC-3'[1]
rs944289 5'-atcaggtaccGGCAATTGAAGTTCCCAAAA-3' 5'-atcactcgagGCCTCCAGACTTGGACTGAG-3'[1]


Labs working on this lncRNA

  • Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Jendrzejewski J, He H, Radomska HS, Li W, Tomsic J, Liyanarachchi S, et al. The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type[J]. Proceedings of the National Academy of Sciences of the United States of America. 2012,109(22):8646-51.

Basic Information

Transcript ID

ENST00000556013.2

Source

Gencode19

Same with

PTCSC3,

Classification

intergenic

Length

571 nt

Genomic location

chr14-:36605314..36645674

Exon number

4

Exons

36605314..36605562,36623010..36623100,36631830..36631889,36645504..36645674

Genome context

Sequence
000001 GAAAGAGGAA AAAAGTGATC TGGGACCTGT TGTTTTTCTT GCATCCCATT TCTACTCTGC CTGTGAGTGA AGACTGTTGT 000080
000081 GGAAAAGTCA ACTGGAGAGA CCAGGTCAAA GGCCAAGCAG AAGAGGAATT AGGCTTAAGA CTGCACTGAG AGGGAACACT 000160
000161 AGACCATGGT GGCAAAATGG CCGAATAGGA GCAGCTCCAG TCTACAGCTC CCAGGGAGAT TAATGCAAAA GATGGAGTCT 000240
000241 CGACACGTTG CCCAAGCTGT TCTCAAACTC CAGGGCTTGA ACAATCTTCC CACCTTGGCC TCCCAAGGCA CTGGAATTAC 000320
000321 AGAGACAGTG CTCTGCAGGG AGTCTACCAC TGTGATGGTT AATACTGAGT GTCAACTTGA TTGGATTGAA GGATGCAAAG 000400
000401 TATTGTTCCT GGGTGTGTCT GTGAGGGTGT TGCCAAAGGA GATTAACATT TGAGTCAGTG GGCTGGGAAA GGTAGACCCA 000480
000481 GCCGTAATCT AGGTGGGCAC CATCTAATCA GCTGCCAGCA CAGCTAGAAG ATAAAGTAGG CAGAAAAACA TGAAAACATT 000560
000561 AGACTGGCCT A
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