ENST00000531381.1

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Please cite: Chunlei Yu (2016) lncRNA: "ENST00000531381.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000531381.1&oldid=1272303 (Last update: Jul 01, 2016). [See details]

MIR100HG, the human miR-99a/100 ~ 125b cluster host gene, locating in the nuclear cell compartment, plays a role in the regulation of erythro-megakaryocytic development.

Contents

Annotated Information

Name

MIR100HG:mir-100-let-7a-2 cluster host gene(HGNC nomenclature)

"adipogenesis down-regulated transcript 1", AGD1, "lncRNA neuronal 2", lncRNA-N2[1]

Characteristics

MIR100HG was localized in the nucleus and their expression correlated with the corresponding miRNA clusters[1].

It was contained in BH3-like motif ,which was associated with the single nucleotide polymorphism (SNP) rs577948, a susceptibility locus for high myopia in Japanese subjects[2].

Cellular Localization

MIR100HG was localized in the nucleus[1].

Disease

myeloid leukemia

Function

Knockdown of MIR100HG impaired cell viability and replating-efficiency of AMKL(acute megakaryoblastic leukemia) cells,which implys MIR100HG may contributes to the maintenance of leukemic growth[1].


Diseases

  • myeloid leukemia

Labs working on this lncRNA

  • Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany[1]
  • School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China[2]

References

  1. 1.0 1.1 1.2 1.3 1.4 Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D, Klusmann JH. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia[J]. Molecular cancer. 2014,13:171.
  2. 2.0 2.1 Zhao F, Bai J, Chen W, Xue A, Li C, Yan Z, et al. Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population[J]. Molecular vision. 2010,16:1920-7.</ref2>(2)

Basic Information

Transcript ID

ENST00000531381.1

Source

Gencode19

Same with

lnc-BLID-1:4,NONHSAT024776,MIR100HG,AGD1, lncRNA-N2

Classification

intergenic

Length

3370 nt

Genomic location

chr11-:121959811..121972886

Exon number

2

Exons

121959811..121962448,121972155..121972886

Genome context

Sequence
000001 GAGACACACT ACAACAGGAG AGGGAGCAAG CGCGAGAGGA TATTAGAAGA GAGGCTTGTC TCCAAGATAT GGAAGGAAGT 000080
000081 GAGAAATGAC AGGGCTGCAA GCTTTGTATG TAGGAGCCCG GCAGGGCGGG GGAGCGGCGA GGAGAGCCAA GTGGATTCTC 000160
000161 AGAAAAGGGG GGAAGCCATC GAAGAGCTAA AGGTGATTAG AGGGGGATAT TGATTTCTTA TTCTGCCAGA GATTTAAGCA 000240
000241 GGCATGCGAG GAATCTGCAC CATGGTTGGC AAAAAGAGAC CCGTTGCCTC CTGTAACCAG ACACTCAGGC TTTCCAGGAG 000320
000321 CCCAGGGAGC AAGCCGAGAA GAAAGGGGGC AGTGTGGTCT AGGAAAATTC AACTTGTCGC TGATTTGTGC CTGATGCCTG 000400
000401 CTGTCCGTCA GCAGCCTCCC TTACAATCTT TTTTTCTCTC TCTCCTTTTT TTTTCCTTGC CTTCTCCTTC TTCACTGAAG 000480
000481 CCTAGGGGAG CCAGTAAAGA TTAAATGTGC TTCTCAAAGG CAGCCACTTC ATGCTGCTAT GTCGAAAGGG CCATTATTAT 000560
000561 TATTATATTT TAATGGTAAA AGAGAAAAGG AGAGAGGTTG AGCGAGCGAG AGAGAAGCTA GGTGTGATGA TGACAGACTA 000640
000641 GCTTTTCTGA GAGGAAAAGG AAAAGGGAAG GGAGAGAAAA AGGAGAGCCT CTGAGCTCAA CGGAGGATTG TGCCTGAGAA 000720
000721 GAACCCACAG AGTTGTGTTG ATGTTCCTTT CAGCTGGTCC TATAGTACCC CTCCTCAGGA ATGTCTCCCC AGTGCAAGGA 000800
000801 CAAAGACTGA AGAGACTGCT ATATTGATGG ACTCTCAAGC CAACTATGAA GTTGAAACAA AGAAAGTGAT CACCTGAAGA 000880
000881 CACCTCCTCT GCTAAGAAAC ACCCCCAAAT TGTGCAGCTT CTGCCACTAG AACTCTCAGA ACAAGAGACA ATCTTTTCAA 000960
000961 GAAACAGAAA AACTCAATAA TGACATCTAG ATTTTCATGA GCCAAGAACT TTCCCTTCCT CATGTGTATT CCTCTGTTTG 001040
001041 TACTTAAATT CATGTGACAT TCATTTTTTT CCTAGTATGG ATATGCTTAT TAATGCACTT GTTTCAAAAT CCCAAATTGC 001120
001121 ACAAATGTGT TAATATTTTA AGAAACAAAA TGAATCCTAC AAGGAGAATG ATTTTTAGCC ACACATAGGG TTGGATCTTG 001200
001201 AGAGTGACCT ACAGAATAAA AGTACTTTTA AAATAAAGTA GTCAGAGGCT ATTCAAAGGG TAAAATAATC ATAGTACCAC 001280
001281 ATTGGTCCAC TTGACACTAA CCAATCGATC ATTTTTTTTT AATCAAGAAA GCTAGATTCT ATCAGATAAA ATCACTGCTT 001360
001361 CTAAAGAGTT TAAATCTAGT TAGAAAAAGT TATAGAAATG TTTGCAAAGA TAAGTAACAG ATAGAGTCAG TAGAGGATAA 001440
001441 GATCAAAAAC AAAACCAAGC AAAAGATGAG TTCAGGGGAG TTTGCCATCA AGTTGGCAAA ACTGACTTAC TTAGGGAAGA 001520
001521 AAGTTATAAA ACAGGAAAAT ATGAGATGAA CCTTGAGTGA TGTGGAAGAT TTAGATAAAT GGAAAGGAAG GAGAAAATGG 001600
001601 AGTTCTTTAG GTGGTTGTAA TTGGAGGAGG AAATGAATAC ACACATCTTG TTGACTTAAA CCCAGACATT CAGCAGCTCT 001680
001681 CTATACATAT CTGGAAAAGA CTGCACAGTC ACCTCCTGTC TCTCACCCCA GGTATTACTT AGAATTATTA TCATATTTCC 001760
001761 CTTCCTTTAA AGTAAGTAAG GGTGATTGGT GACAATATGG AGAACTATGA TTTTTCCATT AACCTAATAA TAATTGGTAT 001840
001841 TTATTGAGTT CTGTTAAGCA TTTTACATAT TAACTCACTT AAGCCTTTCA ACAGCCTTGC AAAATAGGTA TTATTATCCC 001920
001921 CATTTTACAG GCAAGAAAAC TGAGGTTTAA GTAACTTGCC GAAGTGCCAT ATACAGGGCT CACATTCAGT ATTGCAGTTG 002000
002001 CAAAGCTCAT GATCTATAGT GCCAAGTTGC AATATTGTAG TCAATGTCAC AATTATTACC CCTTTTTATA TTCCTTGATA 002080
002081 TTTTTCCATG GCAAACAATT AGCTATTTCA TTTAATAATC ACCTAAAACT TTTCAGTCTT CTGATTAAAA TTACGCTGGA 002160
002161 GTGATAGAAT GTATTTTCAT GATAGAAATT GGGAAAAAAA ATGGGGAATG AAGTTTATCA GCATTTCAGA CTTGTTTTTT 002240
002241 TTTTTTTTTT TTGCAAGACT TTGATGAGAT TGTTCACTTT TGTCTATGTA AAATCCCAAA TCCTTGAGAA TAAAAAAGGG 002320
002321 GGAGGTTTAA GTCACTTGTT GCAATGCCCT TTTTAATAGA GGCAATAAAT CTAAAGGCCA TAAATTTAGA GTGACTTACA 002400
002401 GAAGATCGAA CTTTGGAGTG TGGCAGAGTA AGGGATGGAA ACCGGGCCCT CCAGTTCACT ATCAGTAGCT TTTGCACTGG 002480
002481 TCTGCCCTTC CTAAATTAAG TATGCACTTC AATTTGATGA GTGGAAACAG TCTATCTGGG CAGTAACCAG GGAGCTTTGT 002560
002561 GCCTAGTAGA TTGCTTCTGT TCTGCACTTC TTTGGTTTCC CACCTCAATG TAAAAAATAG CTAGCAATGA AGTCCAGAAG 002640
002641 TTGTCAATGG TTCATCCCCA GAAGAATGCA TAATGTCCAA AGTTGTATGT GTATGATGTC TTCAATGGTA TTAAGTTATT 002720
002721 TCAAATTCTT AGTTCACCTA CATAAATCAT TTCTAACAAG CATCTTCTTA ACCAACTTTA TGCACAGTGT ATGTTTGTAA 002800
002801 GTGCTTCTGC ACGAATGTTT ATACATGACT GTTTCCATAG TACTTATGTT TTTAAAAATA TTCAGTCATT TCCTACTATA 002880
002881 ATCCTCATGT ATCCATGTAA CTGACTCAAA AATACTTCAG CCACAGAAAG CTAAAACTGA GCAAATCTCA TTCTTCTTTT 002960
002961 CCATCCCCTT TGCATGTGGC TGGCATTTAG TAATGATTAA TAATATGGCC AGCTGAATAA CAGAGGTTTG AGACACAATT 003040
003041 CTTTCTCAAA GGAGTCAGCT AAGCTGGGTC TACTTATGGA CAAACATCTA AATGTGTGGA AGTATCTGAT ATTTGACAAT 003120
003121 GGTAAATTTC CACTTAGCTA GCTAGCATTG TCAGACTTCA ATCTCCTCAT GGCTCTGGCC GTCCTGTTTT AAGCATGATA 003200
003201 ATTGTTGGCC ACATCTCACA TAGTTCTCAT TGAGTGAGTT CATAAATAAA CAGGGTTTTT TTTTTTTTTT AAAGAGCAGC 003280
003281 CAAGCACAAA GTGTGACTTT GTTGACATTT TATGTGACTT TGTCATATGT TCCTAACCCC CAATAAAAGC AATGTTGCAT 003360
003361 CAACTGTGAA
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Predicted Small Protein

Name ENST00000531381.1_smProtein_530:640
Length 37
Molecular weight 4510.4008
Aromaticity 0.111111111111
Instability index 55.4111111111
Isoelectric point 9.57720947266
Runs 6
Runs residual 0.0137917637918
Runs probability 0.0272625566743
Amino acid sequence MLLCRKGHYYYYILMVKEKRREVERAREKLGVMMTD
Secondary structure LEEEELLLEEEEEEEEHHHHHHHHHHHHHHLLLLLL
PRMN -
PiMo -
Please cite: Chunlei Yu (2016) lncRNA: "ENST00000531381.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000531381.1&oldid=1272303 (Last update: Jul 01, 2016).
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Chunlei Yu1.507115140.9952016-06-25 14:31:00[show]
Contributors with score < 1 are excluded from the authorship.
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Lin Liu0.03213212016-07-01 20:22:13[show]
Note: For each edit version that is contributed by a specific person, his/her contribution is quantified as its edit quality multiplied by its edit quantity; the edit quantity amounts to the edit distance in comparsion with its previous version (that is, the minimum number of edit operations required to transform one string into the other), and the edit quality corresponds to whether the edit persists in comparison with the last version, ranging from -1, when the edit is entirely reverted (short-lived), to 1, indicating that the edit is totally preserved in the last version (long-lived). Please also note that contribution quantification may take time to reflect recent edits.
*Since one person may perform many discontinuous edits for a wiki page, contribution score is the sum of quantified contributions over all participated edits.
#Multiple successive edits provided by a researcher are counted as one edit.
ΛSummed edit quantity is the sum of edit quantities over all participated edits.
Averaged edit quality is the edit quality normalized over all participated edits.
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