ENST00000526269.2
SENCR is a new vascular cell-enriched, cytoplasmic lncRNA that seems to stabilize the smooth muscle cell contractile phenotype.
Contents
Annotated Information
Name
SENCR: smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA(HGNC nomenclature)
"FLI1 antisense RNA 1", "FLI1 antisense RNA 1 (non-protein coding)", FLI1-AS1[1]
Characteristics
SENCR spanning 1319 bp in 11q24 is transcribed antisense from the 5' end of the FLI1 gene and exists as 2 splice variants[1].
Cellular Localization
SENCR is a cytoplasmic lncRNA[1].
Function
SENCR acting as a fine-tuner of the vascular SMC phenotype[1].
Expression
| Gene | Primer Sequence(Forward) | Primer Sequence(Reverse) | Size(bp) | Application(s) |
|---|---|---|---|---|
| SENCR_V2 | GTAGAGTTTAAGCAGTGTGGAG | GGTGGTGGAGTTGGAGTC | 259 | RT-PCR, fractionation[1] |
| SENCR_V2 | TTACCTTGTCCACGCTCTCC | CCGTCTCTCCGCATTCTCC | 209 | qPCR[1] |
| FLI1 | TGTCTCTTTCGCTCCGCTAC | CTCCTTAATAGTCCCGTCCATTTG | 211 | qPCR[1] |
| 18S | ATGGGCGGCGGAAAATAGC | TCTTGGTGAGGTCAATGTCTGC | 100 | qPCR[1] |
| SENCR_V1/V2 | GTGCGTAGAGTTTAAGCAGTGTGGAGAT | AGGGCAAGTCTTCAATTTAATCTAGTTCCATATTG | RT-PCR, cloning[1] | |
| NEAT1 | TTCCTTCTTCCCTTTAAGTTTCAC | CTTACCATACAGAGCAACATACC | 289 | RT-PCR, fractionation[1] |
| XIST | GAGATAGCTGCCTAGTGGAAATG | CCTATCTGGGACCAGGAAAGTA | 627 | RT-PCR, fractionation[1] |
Labs working on this lncRNA
- Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, et al. Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA[J]. Arteriosclerosis, thrombosis, and vascular biology. 2014,34(6):1249-59.
Basic Information
| Transcript ID |
ENST00000526269.2 |
| Source |
Gencode19 |
| Same with |
SENCR, FLI1-AS1 |
| Classification |
antisense |
| Length |
1298 nt |
| Genomic location |
chr11-:128561567..128565918 |
| Exon number |
3 |
| Exons |
128561567..128562016,128562550..128563286,128565808..128565918 |
| Genome context |
|
| Sequence |
000001 GTGCGTAGAG TTTAAGCAGT GTGGAGATAT TTCTTCACTT TTCCTTAGGG TGTCCACATC AAGACCCTGA GGCCATCTTA 000080
000081 CCACCCTTCT GGATCAGAAG AGGCCTTCAG AGCCCTCCGC TGCCGAGACG CGGCAGACTC CCAGAGCGGC TCACCCACTC 000160 000161 ATCGAAGCGG ATTCTGGGCG GTTTCGGGCT GACCCGCGCT GTCAGGGCGC GGACTCCATT CCGGGCGCAT TGTTAGGAGA 000240 000241 AGGGGCCCCT CGGGGCGGCG CGCCTCGACC CTGGGCTCCC GGTGCCCGCA GAGGGCGGAG ATCCGCGGCG CCCTAGGCCA 000320 000321 CCTATCCGCA TCTTCTCGAG CCAAACCCCC AGCGCTTACC CGGACCCGAC GGCCCAAGCA CTGACTCCCA GGCAAGAGTC 000400 000401 GCCCTTCCTG GTCCCCAGGG AACTGACACT ACCGCGGGAC GTTCCCTCTA GGACAGTCAG CAGGTCCCAG GAGCGCAGCA 000480 000481 CGCAACAGCG CAGAGCAGAC CCAGACTTTT CCCGGGGTGA GACCCGGAGG CCCGCGCTCT GGACCGTCCT CCCTACCCAG 000560 000561 CCTGGAGGCC GGCGTTCCCC GGCCCAACCC GGAGACCTCC CCGCCTCCCT CCTGGGCCGC CGCGCGCCCC AGTTGGAGCA 000640 000641 GCCTCGAGGG GCTGGGCCCT TTCGGCCGGA CTCCCTTCTC CCGGACATCC AAAACAGGTT ACCTTGTCCA CGCTCTCCGG 000720 000721 ACCACGCTTT GGACTTGCTC ACTTTTATTT AAGAGTCCGA CGGGGGAAAG AGGGAAAAAA AATCCAGAGG AGATCCAAGT 000800 000801 CAATTGGAAG AAAAAATTTC AAAAGGGTGT CCACAGAGGC GAAAAAAGCC CAGGCTCTAC CGACCTTCAA ACTACAACAG 000880 000881 AGCTTTCAGG AGAATGCGGA GAGACGGCTT CCCACCCGGA CCTCACCAGA AACCCGCACA CCCCAGCCAC ATTGCTCCTC 000960 000961 ATTCAGCCAG AAAGGACTCC AACTCCACCA CCAGGAGGCC CCCCTTCCTG GTGCTGGCCA GTTGCAGAGG CTGTTCATGG 001040 001041 CATCCCACAG GTGGCGACTG CCCCCCACCC TCCTCCTAGC ACTTTAGAGG GTCCCTCTGT GGCAGACACC ATGGCTAGGT 001120 001121 TTCTCTTTCC AACTCCTGTT GGTCTGGCAA GTGACAGATC ATCTTCACTA CATTAATCAG TAGTCACCCG AACATTCCTA 001200 001201 TACTGTCCCC CAATTCCTTT CAGCACCAGC TGCCTCCCCC ACTGGAATTA TTCAATATGG AACTAGATTA AATTGAAGAC 001280 001281 TTGCCCTTTA GTTTTTAA |
