LUCAT1,a smoke and cancer–associated lncRNA, which regulated by NRF2,is induced by smoke and up-regulated in airways of smokers in many lung cancer cell lines and plays a functional role in mediating protection against cigarette smoke–induced toxicity.
LUCAT1: lung cancer associated transcript 1 (non-protein coding)(HGNC nomenclature)
SCAL1, "smoke and cancer associated lncRNA 1"
LUCAT1, a novel long noncoding RNA (lncRNA), which is located in chromosome 5 and encompass four exons and three introns, is induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer cell lines.
LUCAT1 may be a novel key downstream mediator of NRF2 in regulating the genes responsible for oxidative stress protection, which indicated that LUCAT1 plays a protective role in suppressing smoke-induced toxicity in airway epithelial cells.
The expression of SCAL1 is regulated transcriptionally by nuclear factor erythroid 2-related factor (NRF2).
Its expression is NRF2-dependent.
|RT-PCR||Forward Primer||Reverse Primer|
Labs working on this lncRNA
- Center for Comparative Respiratory Biology and Medicine, Genome and Biomedical Science Facility, and Division of Pulmonary and Critical Care Medicine, School of Medicine, University of California at Davis, Davis, CA 95616, USA.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines[J]. American journal of respiratory cell and molecular biology. 2013,49(2):204-11.
Predicted Small Protein
|Amino acid sequence||MGYMLSYRVSLCRPGWSAVARDLGSLQAPPPGFTPFSCLSLLSSWDYRRPPPHPGIQLAV|