ENST00000452148.2

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PCAT7, 1322 bp long non-coding RNA, prostate cancer associated transcript 7.

Contents

Annotated Information

Name

PCAT7: prostate cancer associated transcript 7 (non-protein coding)(HGNC nomenclature)

PCAN-R2, "prostate cancer-associated noncoding RNA 2"[1]

Characteristics

Prostate Cancer Associated Non-coding RNA 2, abbreviated as PCAN-R2 (Ensembl ID ENSG00000231806). PCAN-R2 showed positive correlation between gene expression and SCNA.[1] PCAN-R2, the major isoform had an extra exon in the 5’end, and the remaining two exons also had different lengths from the Ensembl annotation. The new 5’ exon of PCAN-R2 was more consistent with the profile of H3K4me3, a histone mark of active promoter and the profile of DNase I hypersensitive regions in LNCaP cells.[1]

Function

Associated with cancer subtypes and clinical prognosis, and is a potential driver of cancer progression.[1].

Regulation

The new 5′exon of PCAN-R2 was more consistent with the profile of H3K4me3, a histone mark of active promoter and the profile of DNase I hypersensitive regions (i.e. the regions with an open chromatin state) in LNCaP cells [1].

Expression

PCAN-R2 showed a similar expression across different tissues[1].

Labs working on this lncRNA

  • Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer[J]. Nature structural & molecular biology. 2013,20(7):908-13.

Basic Information

Transcript ID

ENST00000452148.2

Source

Gencode19

Same with

PACT7, PCAN-R2

Classification

antisense

Length

1164 nt

Genomic location

chr9+:97317351..97330409

Exon number

3

Exons

97317351..97317592,97321251..97321434,97329672..97330409

Genome context

Sequence
000001 ATGCGCATAA CCTCAGGATA TAAATAATGC TGAAGCAGAG TTACGTTTTT TTTGTTGTTG TTTTTTTTGT TTTTGTTTTT 000080
000081 TTAGGTTTCC GTGTGTTTCT ATTGAGCTGC TCAGTGCCCG GCTTAGAAGA CCAGGAAAAG GAGTCACAGG TCGTATGCTG 000160
000161 GAGGCTTGAG CCGCGGCACC GTGGCGCGGC TCGCCTCGCT GCGGTTGGTG GTGGCGGTGG ACATTGCAGC GCGGCTGGAG 000240
000241 GGGTGAGATA TTCCTGCACA TCCTCTGGTG ACCCCAGAAT GAGGGGGACT CGCTGGTGAA TTGCCTCGGG CTTCACGTCC 000320
000321 AGTACAGGCT GGGTCCCCGT GGTCGCCAAG CCTCCTGCCT GCTCAATGAT GTAGGCCACG GGATTGCATT CATACAGGAG 000400
000401 CCGGAGCTGT GGAGGAACAG AGGCAGGACA AATTCACCAA GAGCCTAGCA ACATGAAGAG AGATGCCAGG AAGAAGAGAG 000480
000481 AAGCCAGGAA ACAAGCCAAC CGCACAATCC CCACATCAGA GCAGGAGAAG ATGGGGGCCT GCTGGCAGAG CTGGGGCTTG 000560
000561 GCTGTGGTCA CTCTGAACCT GCTCTTTGGT GTTTTCATGA GTGGTGGGAA GAATAGGGAC CATATGGAGC CCACACAGGA 000640
000641 AGCTCTAGCA GTAACACAGC AAGCAGGAAG ACAATTCTAA GGAAGCAGCC CATAGTCTTC TTTCTTTTCC TGTGCATCTT 000720
000721 CCACTGTCAG TGAGGCTCCT CATTTATGGT GAACCCAACT GTGTGTATCT CCCAAGTTCT CACCCGCAGA TTAATGTTTT 000800
000801 CAGGAAGATA GGCCATCAAC AGTGAGAGGA AGAAGTTACA TTGTCGTATG AGGGATGCAT TTTAACCATT AATTTGTGGT 000880
000881 ACAGGCTGGG CGCAGTGGCT TATGCATGTA ATCCCAGCAC TTTGGGAGGC CGAGGTGGGT GGATCACGAG GTCAGGAGAT 000960
000961 CGAGACCATC CTGGCTAACA TGGTGAAACC CCGTCTTTAC TAAATATACA AAAAATTGGC CGGGCGTGGT GGTGGGCACC 001040
001041 TGTAGTCCCA GCTACTCGGG GGGCTGAGGC AGGAGAATGG TGTGAACCCG GGAGGCAGAG CTTGCAGTGA GCCGAGATCG 001120
001121 CGCCACTGCA CTCCAGCCTG GATGACAGAG CAAGACTCCA TCTC
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