ENST00000444042.2

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CYP4A22-AS1, Long non-coding RNA with enhancer-like function in human

Annotated Information

Approved Symbol

CYP4A22-AS1

Approved Name

CYP4A22-AS1: CYP4A22 Antisense RNA 1 NcRNA-A3

Characteristics

CYP4A22-AS1 gene is Spliced, up to 4 exons, ~920 nt transcript.Its loci covers ~ 80kb and is antisense to CYP4A22 and CYP4Z1.[1] CYP4A22-AS1 is transcribed bidirectionally, downstream from TAL1 and PDZK1IP1 on same strand.[1] In-vitro translation of CYP4A22-AS1 showed no sign of protein product.[1]

Function

CYP4A22-AS1 expression stimulates TAL1 gene expression (in MCF7 cells).[1]

Regulation

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Disease

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Expression

Expressed and functionally of CYP4A22-AS1 characterized in MCF7 cells. [1] CYP4A22-AS1 identified as enriched in K562, HelaS3 and HepG2 nuclear fractions. [2]

Labs working on this lncRNA

  • The Wistar Institute, 3601 Spruce Street, Philadelphia
  • Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain

References

  1. 1.0 1.1 1.2 1.3 1.4 Derrien T & Guigo R. Long non-coding RNAs with enhancer-like function in human cells[J]. M S-Med Sci. 2011, 27(4):359-361
  2. Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H et al. The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression[J]. Genome Res. 2012, 22(9):1775-1789

Sequence

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