OVAAL, 1489 nt ovarian adenocarcinoma amplified long non-coding RNA, which is located at the center of a narrowly amplified intergenic segment, contains three annotated exons, appears to have a cytoplasmic non-coding function.
OVAAL: ovarian adenocarcinoma amplified long non-coding RNA(HGNC nomenclature)
LINC01131, "long intergenic non-protein coding RNA 1131", OVAL, "ovarian adenocarcinoma amplified lncRNA"
The OVAL gene, which is located at the center of a narrowly amplified intergenic segment that lacks other annotated genes, contains three annotated exons that give rise to a predicted 1489 nt non-coding RNA, where the large third exon contributes most of the sequence. Many of theOVAL ESTs and mRNAs originated from human melanoma cells.
Its subcellular localization was predominantly cytoplasmic.
OVAL appears to have a cytoplasmic non-coding function that is independent of its protein-coding neighbors.
Reverse transcription PCR
Evolutionary conservation,specific regions in the last exon demonstrated elevated conservation.
Labs working on this lncRNA
- Department of Medical Biochemistry & Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Akrami R, Jacobsen A, Hoell J, Schultz N, Sander C, Larsson E. Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification[J]. PloS one. 2013,8(11):e80306.
lnc-XPR1-2:2, OVAAL, LINC01131, OVAL