ENST00000442621.1

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Please cite: Chunlei Yu (2016) lncRNA: "ENST00000442621.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000442621.1&oldid=1272326 (Last update: Jul 01, 2016). [See details]

OVAAL, 1489 nt ovarian adenocarcinoma amplified long non-coding RNA, which is located at the center of a narrowly amplified intergenic segment, contains three annotated exons, appears to have a cytoplasmic non-coding function.

Contents

Annotated Information

Name

OVAAL: ovarian adenocarcinoma amplified long non-coding RNA(HGNC nomenclature)

LINC01131, "long intergenic non-protein coding RNA 1131", OVAL, "ovarian adenocarcinoma amplified lncRNA"[1]

Characteristics

Properties of OVAL lncRNA[1]

The OVAL gene, which is located at the center of a narrowly amplified intergenic segment that lacks other annotated genes, contains three annotated exons that give rise to a predicted 1489 nt non-coding RNA, where the large third exon contributes most of the sequence. Many of theOVAL ESTs and mRNAs originated from human melanoma cells[1].

Cellular Localization

Its subcellular localization was predominantly cytoplasmic[1].

Disease

ovarian cancer

Function

OVAL appears to have a cytoplasmic non-coding function that is independent of its protein-coding neighbors[1].

Expression

Reverse transcription PCR

Primer Forward Reverse
OVAL 5'-AGGCCAATATGCAGACAAGG-3' 5'-AGTTCTCCAGTGGGGGTCTT-3'[1]
ACTB 5'-ACTCTTCCAGCCTTCCTTCC-3' 5'-GTACTTGCGCTCAGGAGGAG-3'[1]

Evolution

Evolutionary conservation,specific regions in the last exon demonstrated elevated conservation.

Labs working on this lncRNA

  • Department of Medical Biochemistry & Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Akrami R, Jacobsen A, Hoell J, Schultz N, Sander C, Larsson E. Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification[J]. PloS one. 2013,8(11):e80306.

Basic Information

Transcript ID

ENST00000442621.1

Source

Gencode19

Same with

lnc-XPR1-2:2, OVAAL, LINC01131, OVAL

Classification

intergenic

Length

1489 nt

Genomic location

chr1+:180528112..180535654

Exon number

3

Exons

180528112..180528191,180531340..180531480,180534387..180535654

Genome context

Sequence
000001 TGCCACTGCC ATGTAAGAAG TGCCTTTCAC CACCCCCACA CCCTGCCATG ACTCTGAGGC CTCCCCAGCC ACGTGGAACT 000080
000081 GAGGCAGCTG TATGGAGGCC AATATGCAGA CAAGGGAAGT AACTCAGGCA TTTTGGGGGA GAGGTACAGA AAGAAGAGAA 000160
000161 AAGACTGAAC TGACTGCTGT TCTGAACAAG AACTGTGACT ATATGTGGTA CTCCCAGAAT GCTGGTTTCC TTTCAGACCC 000240
000241 ATCAAGTGGC CATCCTATTG GCTTGGACTG AAGACCCCCA CTGGAGAACT GTCTCTGCAG CCTATACTGA TGACACTGGC 000320
000321 CACTGTCCAG GGCTCCACCC CAAGGAGTCC AAGCCCCAGA CATTTAGCCT TAGAGAGAAT CCAGATTTTG CATTTCCAGT 000400
000401 GCAGGGATTG ATGGAGCCTT GTGTATCAAA GTGCCAATTT CTTTCTAACA AGCTAGGGAG GATACCGTTG ACAGCAGCAG 000480
000481 AAAGGGGTAG CAGTGGTTTG CTTTCCAAAT GGTAATAAGA AGGGCCTGGC AGTGGCAACC TGTCCACGTA TCATTAAAAA 000560
000561 TGGACTCTCC TGCTTCGTTT GGAATTCAAC CCAATGAACT TGAATAAACT CTGGACAATG ACCAGCACAG AGCCCTAAGC 000640
000641 AGGATACAGC AAGATTATTT GCTTTACTCA TCCACTGAGT ACCTACCATG TGCCAAATAC TATGCTATAT GCCGAGTATA 000720
000721 CACTGGCAAA TAAAACAGAT ATGGTCCCTG GAGCCTATGA ATCTTACCCC ATCTAGCCAC AAATAATAAA AATAAGAAGA 000800
000801 ATCTGAAGGA CAAGTGGGAC AGAAATACTC AAGCAGAATG AGGGTGAGAT TGAAGTCCCT GAACATACAG TGCCCTTTAC 000880
000881 ACTTGATCTT AGCCAAAAGG CCGAGAAGAG ATTACAGTGC TTTTTAAAGG TAGCATTTCA CCCAGCCAAT AATCAATCCC 000960
000961 TTTGGCCTTC TTGAGGTGCA AGGCCACACA CTCAAATTCT TTAATCAAAC AATAGGCTAG TGCAAATGGA GCTATTTCTT 001040
001041 AAACCCAGCT GTTTACACAG CAGCTACAAA TCTGTTCAGA AGGAATCCCC CACCATCCAC AACTGTCTAT CGAGCAGATG 001120
001121 TGCAAGAGTA TTTGTCTCTC ACCACCAGGG TTGCAGTCAG GACAAGAGAG CAGGTTTGAA CGTCTTCGGC TCCTAGAACT 001200
001201 GCACAAGCTG TGTCTTCAGT GCCCAGAGGC GGCTGCAACG TCTCCCCAGT TCTCCTCTCA GAACAATGGA AATTTTTTTT 001280
001281 AGAGGCGTAA TAGGAAGGTT TGCATTGAAT TATTAAACAA TGGGTATTGA AAAATATGTT TTCTTTGACC TCTGTACTTC 001360
001361 TAGCTTTTAC CAGTCAGTGT TTTCTTGTAC CAAGGCTAAG ATATGTATAA CACTGAAATG GATGTCTTCT TATATAATAT 001440
001441 TTTACAAGCT TTTGAAAACC TGTGCCCTTT AATAAATTTT AAAACGTTT
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Please cite: Chunlei Yu (2016) lncRNA: "ENST00000442621.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000442621.1&oldid=1272326 (Last update: Jul 01, 2016).
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Chunlei Yu1.726117560.9832015-04-15 13:23:36[show]
Contributors with score < 1 are excluded from the authorship.
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Lin Liu0.03113112016-07-01 21:26:45[show]
Lina Ma0.02312312016-06-25 13:51:51[show]
Note: For each edit version that is contributed by a specific person, his/her contribution is quantified as its edit quality multiplied by its edit quantity; the edit quantity amounts to the edit distance in comparsion with its previous version (that is, the minimum number of edit operations required to transform one string into the other), and the edit quality corresponds to whether the edit persists in comparison with the last version, ranging from -1, when the edit is entirely reverted (short-lived), to 1, indicating that the edit is totally preserved in the last version (long-lived). Please also note that contribution quantification may take time to reflect recent edits.
*Since one person may perform many discontinuous edits for a wiki page, contribution score is the sum of quantified contributions over all participated edits.
#Multiple successive edits provided by a researcher are counted as one edit.
ΛSummed edit quantity is the sum of edit quantities over all participated edits.
Averaged edit quality is the edit quality normalized over all participated edits.
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