ENST00000430058.1

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PTCSC2,shorted for papillary thyroid carcinoma susceptibility candidate 2, may functions in papillary thyroid cancer.

Contents

Annotated Information

Name

PTCSC2:papillary thyroid carcinoma susceptibility candidate 2 (non-protein coding)(HGNC nomenclature)

Disease

Figure: Gene expression analysis of PTCSC2 in PTC tumors. [1].

thyroid carcinoma

PubmedID

25303483

Characteristics

PTCSC2, a 1635 bp long intergenic noncoding RNA gene and locus in 9q22.33,named papillary thyroid cancer susceptibility candidate 2 (PTCSC2)[1].

Function

PTCSC2 plays an important role in the predisposition to PTC(papillary thyroid cancer)[1].

Regulation

PTCSC2 is involved in the regulation and interaction of coding and noncoding genes[1]. The cells transfected with the PTCSC2-c construct showed a strong RT-PCR band in the presence of reverse transcriptase, but not in the absence of reverse transcriptase.[1].

Expression

Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of noncoding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer [1].

Labs working on this lncRNA

  • Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 He H, Li W, Liyanarachchi S, Jendrzejewski J, Srinivas M, Davuluri RV, et al. Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2[J]. The Journal of clinical endocrinology and metabolism. 2015,100(1):E164-72.

Basic Information

Transcript ID

ENST00000430058.1

Source

Gencode19

Same with

lnc-C9orf156-3:1,NONHSAT133533,PTCSC2

Classification

intergenic

Length

204 nt

Genomic location

chr9-:100568217..100572290

Exon number

2

Exons

100568217..100568306,100572177..100572290

Genome context

Sequence
000001 TGTCCTGGGG GAATAATTAT GTTCCCTGTC TTGGGAGCCT TTCTTCAGGG AGCTTGATGG TTCCAACCCA CCCAGGAGCC 000080
000081 TGGGACATCT GTGCCCCTGG GCAATCCCCT GCAGTTTCCT GATTCCAAGA TGAGGGGGTA GAATCCGAAG ATCTCCAAGG 000160
000161 CCTTGATGAG TGCTACCAGT CTGCAAATTC CCAAGCCAAG TTCT
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