ENST00000414795.1

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NRIR(also namedlncRNA-CMPK2), a spliced, polyadenylated nuclear transcript that was induced by IFN acts as a negative regulator of the IFN response.

Contents

Annotated Information

Name

NRIR: negative regulator of interferon response (non-protein coding)(HGNC nomenclature)

lncRNA-CMPK2[1]

Cellular Localization

  • nuclear
Characterization of lncRNA-CMPK2 [1].

Characteristics

LncRNA-CMPK2, which was locacted on chromosome 2p25.2 and spans 832 bp long, was a spliced, polyadenylated nuclear transcript that was induced by IFN in diverse cell types from human and mouse[1].

Function

The IFN-induced lncRNA-CMPK2 acts as a negative regulator of the IFN response, at least partially through suppression of transcription of a subset of antiviral ISGs. Further, the level of lncRNA-CMPK2 was increased in liver samples from patients chronically infected with HCV[1].

Regulation

LncRNA-CMPK2 is a bona fide ISG induced by both type I and type II IFNs[1].

Evolution

IFN-mediated induction of lncRNA-CMPK2 is likely conserved among mammals and is not tissue-specific, but rather part of the global transcriptional response to IFN stimulation[1].

Labs working on this lncRNA

  • Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Kambara H, Niazi F, Kostadinova L, Moonka DK, Siegel CT, Post AB, et al. Negative regulation of the interferon response by an interferon-induced long non-coding RNA[J]. Nucleic acids research. 2014,42(16):10668-80.

Basic Information

Transcript ID

ENST00000414795.1

Source

Gencode19

Same with

lnc-CMPK2-1:1,NONHSAT068918,NRIR,lncRNA-CMPK2

Classification

intergenic

Length

506 nt

Genomic location

chr2-:6969011..6980595

Exon number

4

Exons

6969011..6969086,6970099..6970237,6973445..6973561,6980422..6980595

Genome context

Sequence
000001 TTCAATCCCA CCCTTCCTTA CCAGATACTA AAGTCATTTC TACCTTTCCT CTTGAGATTT GCTGTTAGAT ATTAGAACTT 000080
000081 CTCTTTGTCA CATACTTACA GGGAGATTTT GATTATCCAT GGGATTCCAT TCATAACCTC ATAAACCACC CCCACGAAGA 000160
000161 AATTATATAT CTCGAAGAGG TTATATGGGC ACATTGTGAG ATGGTGGCCT CCCATGAGCC AAGAAAAGAG GGCTTAAAAT 000240
000241 GAATCCTACC TGGCTGGCAC CTTGATCTTG GACTTCCTAG CATCCAGAAA TGTGACATGG TTTTCTGGTG CCTTGGCAAC 000320
000321 TGCTCACGAT GCATGGGAAG ACTAAACACT TTGTGTACAG CATTCTGTCT CATCCAGTGA AGACTTCCTC TGGATTATTG 000400
000401 CAGCAGACAC CTCTAACCTC CTTAATCTGT ACTGAATCTT GCTCTGTCGC CAGGCTGGAG TGCAGTGGTG CGATATTGGC 000480
000481 TCACTGCAAC CTCCGCCTCT CGGGTT
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Predicted Small Protein

Name ENST00000414795.1_smProtein_296:379
Length 28
Molecular weight 3084.7697
Aromaticity 0.111111111111
Instability index 47.8222222222
Isoelectric point 8.41741943359
Runs 5
Runs residual 0.0214707461084
Runs probability 0.0334393216747
Amino acid sequence MVFWCLGNCSRCMGRLNTLCTAFCLIQ
Secondary structure LEEEELLLLLHHHHHHHHHHHHHHHLL
PRMN -
PiMo -
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