NRIR(also namedlncRNA-CMPK2), a spliced, polyadenylated nuclear transcript that was induced by IFN acts as a negative regulator of the IFN response.
NRIR: negative regulator of interferon response (non-protein coding)(HGNC nomenclature)
LncRNA-CMPK2, which was locacted on chromosome 2p25.2 and spans 832 bp long, was a spliced, polyadenylated nuclear transcript that was induced by IFN in diverse cell types from human and mouse.
The IFN-induced lncRNA-CMPK2 acts as a negative regulator of the IFN response, at least partially through suppression of transcription of a subset of antiviral ISGs. Further, the level of lncRNA-CMPK2 was increased in liver samples from patients chronically infected with HCV.
LncRNA-CMPK2 is a bona fide ISG induced by both type I and type II IFNs.
IFN-mediated induction of lncRNA-CMPK2 is likely conserved among mammals and is not tissue-specific, but rather part of the global transcriptional response to IFN stimulation.
Labs working on this lncRNA
- Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Kambara H, Niazi F, Kostadinova L, Moonka DK, Siegel CT, Post AB, et al. Negative regulation of the interferon response by an interferon-induced long non-coding RNA[J]. Nucleic acids research. 2014,42(16):10668-80.
Predicted Small Protein
|Amino acid sequence||MVFWCLGNCSRCMGRLNTLCTAFCLIQ|