ENST00000414795.1

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Please cite: Chunlei Yu (2016) lncRNA: "ENST00000414795.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000414795.1&oldid=1272109 (Last update: Jun 30, 2016). [See details]

NRIR(also namedlncRNA-CMPK2), a spliced, polyadenylated nuclear transcript that was induced by IFN acts as a negative regulator of the IFN response.

Contents

Annotated Information

Name

NRIR: negative regulator of interferon response (non-protein coding)(HGNC nomenclature)

lncRNA-CMPK2[1]

Cellular Localization

  • nuclear
Characterization of lncRNA-CMPK2 [1].

Characteristics

LncRNA-CMPK2, which was locacted on chromosome 2p25.2 and spans 832 bp long, was a spliced, polyadenylated nuclear transcript that was induced by IFN in diverse cell types from human and mouse[1].

Function

The IFN-induced lncRNA-CMPK2 acts as a negative regulator of the IFN response, at least partially through suppression of transcription of a subset of antiviral ISGs. Further, the level of lncRNA-CMPK2 was increased in liver samples from patients chronically infected with HCV[1].

Regulation

LncRNA-CMPK2 is a bona fide ISG induced by both type I and type II IFNs[1].

Evolution

IFN-mediated induction of lncRNA-CMPK2 is likely conserved among mammals and is not tissue-specific, but rather part of the global transcriptional response to IFN stimulation[1].

Labs working on this lncRNA

  • Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Kambara H, Niazi F, Kostadinova L, Moonka DK, Siegel CT, Post AB, et al. Negative regulation of the interferon response by an interferon-induced long non-coding RNA[J]. Nucleic acids research. 2014,42(16):10668-80.

Basic Information

Transcript ID

ENST00000414795.1

Source

Gencode19

Same with

lnc-CMPK2-1:1,NONHSAT068918,NRIR,lncRNA-CMPK2

Classification

intergenic

Length

506 nt

Genomic location

chr2-:6969011..6980595

Exon number

4

Exons

6969011..6969086,6970099..6970237,6973445..6973561,6980422..6980595

Genome context

Sequence
000001 TTCAATCCCA CCCTTCCTTA CCAGATACTA AAGTCATTTC TACCTTTCCT CTTGAGATTT GCTGTTAGAT ATTAGAACTT 000080
000081 CTCTTTGTCA CATACTTACA GGGAGATTTT GATTATCCAT GGGATTCCAT TCATAACCTC ATAAACCACC CCCACGAAGA 000160
000161 AATTATATAT CTCGAAGAGG TTATATGGGC ACATTGTGAG ATGGTGGCCT CCCATGAGCC AAGAAAAGAG GGCTTAAAAT 000240
000241 GAATCCTACC TGGCTGGCAC CTTGATCTTG GACTTCCTAG CATCCAGAAA TGTGACATGG TTTTCTGGTG CCTTGGCAAC 000320
000321 TGCTCACGAT GCATGGGAAG ACTAAACACT TTGTGTACAG CATTCTGTCT CATCCAGTGA AGACTTCCTC TGGATTATTG 000400
000401 CAGCAGACAC CTCTAACCTC CTTAATCTGT ACTGAATCTT GCTCTGTCGC CAGGCTGGAG TGCAGTGGTG CGATATTGGC 000480
000481 TCACTGCAAC CTCCGCCTCT CGGGTT
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Predicted Small Protein

Name ENST00000414795.1_smProtein_296:379
Length 28
Molecular weight 3084.7697
Aromaticity 0.111111111111
Instability index 47.8222222222
Isoelectric point 8.41741943359
Runs 5
Runs residual 0.0214707461084
Runs probability 0.0334393216747
Amino acid sequence MVFWCLGNCSRCMGRLNTLCTAFCLIQ
Secondary structure LEEEELLLLLHHHHHHHHHHHHHHHLL
PRMN -
PiMo -
Please cite: Chunlei Yu (2016) lncRNA: "ENST00000414795.1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=ENST00000414795.1&oldid=1272109 (Last update: Jun 30, 2016).
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Chunlei Yu1.213113050.932016-06-25 14:32:42[show]
Contributors with score < 1 are excluded from the authorship.
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Lin Liu0.183118312016-06-30 13:12:10[show]
Note: For each edit version that is contributed by a specific person, his/her contribution is quantified as its edit quality multiplied by its edit quantity; the edit quantity amounts to the edit distance in comparsion with its previous version (that is, the minimum number of edit operations required to transform one string into the other), and the edit quality corresponds to whether the edit persists in comparison with the last version, ranging from -1, when the edit is entirely reverted (short-lived), to 1, indicating that the edit is totally preserved in the last version (long-lived). Please also note that contribution quantification may take time to reflect recent edits.
*Since one person may perform many discontinuous edits for a wiki page, contribution score is the sum of quantified contributions over all participated edits.
#Multiple successive edits provided by a researcher are counted as one edit.
ΛSummed edit quantity is the sum of edit quantities over all participated edits.
Averaged edit quality is the edit quality normalized over all participated edits.
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