LINC01191, a 869bp long non-coding RNA, which is induced by several IAV(influenza A virus) strains (H1N1, H3N2, H7N7) as well as vesicular stomatitis virus, functions in IAV propagation.
LINC01191: long intergenic non-protein coding RNA 1191(HGNC nomenclature)
lnc-ACTR3, VIN, "virus inducible lincRNA" 
LINC01191,virus inducible lincRNA (VIN), is induced by several IAV(influenza A virus) strains (H1N1, H3N2, H7N7) as well as vesicular stomatitis virus. 
VIN is localized to the host cell nucleus. 
VIN expression was specifically induced upon infection with a number of IAV and VSV(vesicular stomatitis virus), suggesting that this lincRNA may have broader functionality during virus infection.
VIN adopts stable secondary structures, and thus, has a functional role in cells, perhaps in complex with other cellular components as it was largely insensitive to endonuclease.
Nuclear expression of VIN suggests an involvement in gene-regulatory processes and VIN is functionally relevant during pathogenesis of IAV infection which strengthens the view that lncRNAs are major players in diverse biological processes. 
VIN is functionally relevant during pathogenesis of IAV infection. 
VIN expression seems to be a specific response to certain viral infections including IAV and VSV, suggesting that this lincRNA may have broader functionality during virus infection. IBV, viral RNA mimics, or IFNβ are not able to induce VIN, this induction is likely to be a specific response and not due the presence of viral RNA itself.
|VIN siRNA 1||CTGTGACATGTAGATTGCTAA||_|
|VIN siRNA 2||CCGGAGCCGTTTACAGTTTGA||_|
|VIN siRNA 3||CGCGCCCTGTCCCGCCATATA||_|
Labs working on this lncRNA
- Department of Molecular Biology; Max Planck Institute for Infection Biology; Berlin, Germany
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Winterling C, Koch M, Koeppel M, Garcia-Alcalde F, Karlas A, Meyer TF. Evidence for a crucial role of a host non-coding RNA in influenza A virus replication[J]. RNA biology. 2014,11(1):66-75.