Approved symbol: ELF3-AS1:ELF3 antisense RNA 1
Approved symbol: ENST00000415582 , SCAT7
HGNC ID: HGNC:40211
LncBook transcript ID: HSALNT0288941
ELF3-AS1 may be used as novel and minimally invasive markers for the diagnosis and prognostic assessment of non-131I-avid lung metastases from Papillary Thyroid Cancer(PTC) . ELF3-AS1 has high diagnostic sensitivity and specificity for predicting non-131I-avid lung metastases of PTC, and low ELF3-AS1 lncRNA level is associated with better prognosis of PTC patients with lung metastases (P<0.001) .
Depletion of SCAT7 in Caki-2 cells altered cell proliferation, inhibited cell cycle progression, and induced apoptosis. SCAT7 interacts with hnRNPK/YBX1 complex and affects cancer cell hallmarks through the regulation of FGF/FGFR and its downstream PI3K/AKT and MAPK pathways.
ELF3-AS1 is significantly upregulated in samples from the non-131I-avid lung metastasis group comparing with 131I-avid lung metastasis group(p<0.05) .
SCAT7 was upregulated in multiple cancers (BLCA, BRCA, KIRP, LIHC, LUAD, LUSC, PRAD, and UCEC). The temporal expression analysis of SCAT7 during cell cycle progression indicated elevated levels in the S-phase of HeLa and Caki-2 cell lines.
Papillary Thyroid Cancer 
Multiple cancers including BLCA, BRCA, KIRP, LIHC, LUAD, LUSC, PRAD, and UCEC.
>XR_426886.2 PREDICTED: Homo sapiens uncharacterized LOC102723465 (LOC102723465), ncRNA
Labs working on this lncRNA
- Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
- Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
- Qiu ZL, Shen CT, Sun ZK, Wei WJ, Zhang XY, Song HJ, Luo QY. Circulating Long Non-Coding RNAs Act as Biomarkers for Predicting 131I Uptake and Mortality in Papillary Thyroid Cancer Patients with Lung Metastases. Cell Physiol Biochem. 2016;40(6):1377-1390.
- Ali MM, Akhade VS, Kosalai ST, Subhash S, Statello L, Meryet-Figuiere M, Abrahamsson J, Mondal T, Kanduri C. PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers. Nat Commun. 2018 Feb 28;9(1):883. doi: 10.1038/s41467-018-03265-1.