Disease: gastric cancer (PMID:24958102)
Dysfunction type: NA
Description: The lncRNA MRUL, was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression levels of MRUL in GC tissues were negatively correlated with in vitro growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicated a poor prognosis for GC patients. MRUL plays a positive role in the regulation of ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines.
Function Mechanism: NA (PMID:24958102)
Biological Process: pathogenic process