DM1-AS:DM1 locus antisense RNA
DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat . Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients .
DM1-AS transcripts are present in both the nucleus and the cytoplasm .
DM1-AS expression appears upregulated in patients, but transcript abundance remains very low . Comparison among different tissues shows that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle .
Myotonic dystrophy type 1 
Labs working on this lncRNA
- a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands.
- Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.