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Annotated Information


DM1-AS:DM1 locus antisense RNA


DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat [1]. Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients [1].

Cellular Localization

DM1-AS transcripts are present in both the nucleus and the cytoplasm [1].


The DM1-AS transcript is a low-abundance RNA[1].

DM1-AS expression appears upregulated in patients, but transcript abundance remains very low [1]. Comparison among different tissues shows that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle [1].


Myotonic dystrophy type 1 [1]

Labs working on this lncRNA

  • a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands.


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.