Disease: gastric cancer (PMID:26549025)
Dysfunction type: interaction
Description: BC032469, a novel lncRNA, expressed highly in gastric cancer tissues, and the upregulation was clinically associated with larger tumor size, poor differentiation and shorter survival of gastric cancer patients. Mechanistically, BC032469 could directly bind to miR-1207-5p and effectively functioned as a sponge for miR-1207-5p to modulate the derepression of hTERT. Thus, BC032469 may function as a ceRNA to impair miR-1207-5p-dependent hTERT downregulation, it may be clinically valuable as a poor prognostic biomarker of gastric cancer.
Function Mechanism: ceRNA (PMID:26549025)
Biological Process: pathogenic process