CT70

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Annotated Information

Name

Approved symbol: CT70

Approved name: cancer/testis associated transcript 70

HGNC ID: HGNC:37195

Previous names: cancer/testis antigen 70

Alias symbols: LeXis

RefSeq ID: XR_001746866

Characteristics

Schematic representation of the LeXis gene locus((Sallam T 2016))

LeXis, named as "Liver-expressed LXR-induced sequence", it's gene locus Lie in close proximity to the canonical LXR target gene Abca1 in mouse((Sallam T 2016)), was distinct gene with Abca1, almost exclusively located in the insoluble nuclear pellet in fractionation studies, along with the known nuclear lncRNAs XIST and histone H3.

Expression

The highly expressed in primary mouse hepatocytes treated with GW3965((Sallam T 2016)) and upregulated in OS(Osteosarcoma) tissues((Wang G 2017)).

Regulation

Please input evolution information here.

Function

LeXis functions as a ceRNA of β-catenin((Wang G 2017))

LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism((Sallam T 2016)).

LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth((Wang G 2017)).

Disease

  • osteosarcoma
  • colon adenocarcinoma [1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
  • Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

References

  1. Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.

Annotation originally sourced from lncRNAdb.