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Annotated Information


Approved symbol: CT70

Approved name: cancer/testis associated transcript 70


Previous names: cancer/testis antigen 70

Alias symbols: LeXis

RefSeq ID: XR_001746866


Schematic representation of the LeXis gene locus((Sallam T 2016))

LeXis, named as "Liver-expressed LXR-induced sequence", it's gene locus Lie in close proximity to the canonical LXR target gene Abca1 in mouse((Sallam T 2016)), was distinct gene with Abca1, almost exclusively located in the insoluble nuclear pellet in fractionation studies, along with the known nuclear lncRNAs XIST and histone H3.


The highly expressed in primary mouse hepatocytes treated with GW3965((Sallam T 2016)) and upregulated in OS(Osteosarcoma) tissues((Wang G 2017)).


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LeXis functions as a ceRNA of β-catenin((Wang G 2017))

LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism((Sallam T 2016)).

LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth((Wang G 2017)).


  • osteosarcoma
  • colon adenocarcinoma [1]


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Labs working on this lncRNA

  • No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
  • Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.


  1. Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.

Annotation originally sourced from lncRNAdb.