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Annotated Information


COL1A2-AS1:COL1A2 antisense RNA 1



LncRNA8975-1(TCONS_00013888 in UCSC hg38; also named NONHSAT122029 in NONCODEv4) is an lncRNA located upstream of the COL1A2 gene on chromosome 7(UCSC hg38, chr7:94278999-94392179, ChIPBase named it lncRNA8975-1). In addition, lncRNA8975-1 is a transcript of 352 nucleotides and comprises 5 exons(NONHSAT122029 in NONCODEv4) based on bioinformatics analyses. LncRNA8975-1 contains no overlapping sequence with the transcripts from its neighbouring gene COL1A2 and is a natural antisense lncRNA. [1]


Effects of knocking down or overexpressing lncRNA8975-1 on collagen synthesis and α-SMA in HSFs[1].

Dysregulation of lncRNA8975-1 can affect collagen and α-SMA expression in fibroblasts. Further more, knockdown of lncRNA8975-1 significantly increases cell proliferation, whereas overexpression of lncRNA8975-1 inhibits HSF(hypertrophic scar fibroblasts) cell proliferation.[1]


Expression of lncRNA8975-1 in hypertrophic scar tissues and fibroblasts [1].

The expression of lncRNA8975-1 is significantly overexpressed in hypertrophic scar tissues compared to normal skin tissues. Furthermore, lncRNA8975-1 expression in hypertrophic scar fibroblasts (HSF) is higher than in normal skin fibroblasts (NSF). [1]

Labs working on this lncRNA

  • State key Laboratory of Reproductive Medicine, Department of Plastic&Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.


  1. 1.0 1.1 1.2 1.3 1.4 1.5 Li J, Chen L, Cao C, Yan H, Zhou B, Gao Y, Li Q, Li J. The Long Non-Coding RNA LncRNA8975-1 is Upregulated in Hypertrophic Scar Fibroblasts and Controls Collagen Expression. Cell Physiol Biochem. 2016;40(1-2):326-334.