Disease: rheumatoid arthritis (PMID:26673966)
Dysfunction type: locus
Description: LncRNAs can regulate the transcript levels of genes in the same genomic region.However, lncRNAs linked to the transcription of candidate risk genes in loci associated to rheumatoid arthritis (RA) have not yet been identified.Our data show the identification of a novel lncRNA C5T1lncRNA that is fully located in the associated region and influences transcript levels of C5, a gene previously linked to RA pathogenesis.
Function Mechanism: transcriptional regulation (PMID:26673966)
Biological Process: pathogenic process